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Q8A0X7

- TRMB_BACTN

UniProt

Q8A0X7 - TRMB_BACTN

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511S-adenosyl-L-methionineUniRule annotation
Binding sitei76 – 761S-adenosyl-L-methionineUniRule annotation
Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation
Active sitei125 – 1251By similarity
Binding sitei125 – 1251S-adenosyl-L-methionineUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-3970-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:BT_3894
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252tRNA (guanine-N(7)-)-methyltransferasePRO_0000171296Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_3894.

Structurei

3D structure databases

ProteinModelPortaliQ8A0X7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
InParanoidiQ8A0X7.
KOiK03439.
OMAiGCGKGEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8A0X7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKNKLEKFA DMASYPHVFE YPYSAVDNVP FDMKGKWHQE FFGNDHPIVL
60 70 80 90 100
ELGCGRGEYT VGLGRMFPDK NFIAVDIKGS RMWTGATESL QAGMKNVAFL
110 120 130 140 150
RTNIEIIERF FAAGEVSEIW LTFSDPQMKK ATKRLTSTYF MERYRKFLKP
160 170 180 190 200
DGIIHLKTDS NFMFTYTKYM IEANQLPVEF ITEDLYHSDL VDDILSIKTY
210 220 230 240 250
YEQQWLDRGL NIKYIKFRLP QEGVLQEPDV EIELDPYRSY NRSKRSGLQT

SK
Length:252
Mass (Da):29,494
Last modified:May 29, 2007 - v2
Checksum:iEA78C50BFAA35710
GO

Sequence cautioni

The sequence AAO78999.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO78999.1. Different initiation.
RefSeqiNP_812805.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO78999; AAO78999; BT_3894.
GeneIDi1073797.
KEGGibth:BT_3894.
PATRICi21062820. VBIBacThe70966_3959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO78999.1 . Different initiation.
RefSeqi NP_812805.1. NC_004663.1.

3D structure databases

ProteinModelPortali Q8A0X7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_3894.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO78999 ; AAO78999 ; BT_3894 .
GeneIDi 1073797.
KEGGi bth:BT_3894.
PATRICi 21062820. VBIBacThe70966_3959.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
InParanoidi Q8A0X7.
KOi K03439.
OMAi GCGKGEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci BTHE226186:GJXV-3970-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiTRMB_BACTN
AccessioniPrimary (citable) accession number: Q8A0X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3