Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD kinase

Gene

nadK

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84Proton acceptorUniRule annotation1
Binding sitei89NADUniRule annotation1
Binding sitei187NADUniRule annotation1
Binding sitei222NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 85NADUniRule annotation2
Nucleotide bindingi157 – 158NADUniRule annotation2
Nucleotide bindingi198 – 203NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE:G13PU-8895-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:BT_3917
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206001 – 302NAD kinaseAdd BLAST302

Proteomic databases

PaxDbiQ8A0V4
PRIDEiQ8A0V4

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_3917

Structurei

3D structure databases

SMRiQ8A0V4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
InParanoidiQ8A0V4
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A0V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPILQPKLMK QLMKFAIFGN TYQPKKSLHA LRLFELLKKQ GAEICMCREF
60 70 80 90 100
YQFLTADLKM EVPVDALLEG NDFTADMVIS IGGDGTFLKA ARRVGRKQIP
110 120 130 140 150
ILGINTGRLG FLADVSPEEM EVTFEEIQAG RYSVEERSVL QLICNDRNLQ
160 170 180 190 200
ESPYALNEIA VLKRDSSSMI SIRTAINGAY LNTYQADGLV IATPTGSTAY
210 220 230 240 250
SLSVGGPIIV PHSNTIAITP VAPHSLNVRP IVIRDDWEIT LDVESRSHNF
260 270 280 290 300
LVAIDGSSET CKETTQLTIR RADYSIKVVK RFNHIFFDTL RSKMMWGADG

RR
Length:302
Mass (Da):33,777
Last modified:June 1, 2003 - v1
Checksum:iB1C1F0677DCA320D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO79022.1
RefSeqiNP_812828.1, NC_004663.1
WP_008760837.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO79022; AAO79022; BT_3917
GeneIDi1075328
31615059
KEGGibth:BT_3917
PATRICifig|226186.12.peg.3981

Similar proteinsi

Entry informationi

Entry nameiNADK_BACTN
AccessioniPrimary (citable) accession number: Q8A0V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health