Reviewed, UniProtKB/Swiss-Prot Q8A0U2 (TPIS_BACTN)

Names and origin

Protein names

Recommended name:
    Triosephosphate isomerase
      Short name=TIM
    EC=5.3.1.1
Alternative name(s):
    Triose-phosphate isomerase

Gene names

Name:	tpiA
Ordered Locus Names:	BT_3929

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Triosephosphate isomerase HAMAP MF_00147		PRO_0000090180
Sites
	Active site	96	1	Electrophile By similarity
	Active site	167	1	Proton acceptor By similarity
	Binding site	9	1	Substrate By similarity
	Binding site	11	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8A0U2-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D61D75B93646FA4E	FASTA	252	26,802
	10 20 30 40 50 60 MRKNIVAGNW KMNKTLQEGI ALAKELNEAL ANEKPNCDVI ICTPFIHLAS VTPLVDAAKI 70 80 90 100 110 120 GVGAENCADK ASGAYTGEVS AEMVASTGAK YVILGHSERR AYYGETVAIL EEKVKLALAN 130 140 150 160 170 180 GLTPIFCIGE VLEEREANKQ NEVVAAQMES VFSLSAEDFS KIILAYEPVW AIGTGKTASP 190 200 210 220 230 240 EQAQEIHAFI RSIVADKYGK EIADNTSILY GGSCKPSNAK ELFSNPDVDG GLIGGAALKV 250 SDFKGIIDAF NA

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO79034.1.
RefSeq	NP_812840.1.
3D structure databases
HSSP	HSSP built from PDB template 1TPH based on UniProtKB P00940.
ModBase	Search...
Genome annotation databases
GeneID	1071892.
GenomeReviews	Gene locus BT_3929 in contig AE015928_GR.
KEGG	bth:BT_3929.
NMPDR	fig|226186.1.peg.3927.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8A0U2.
OMA	IGAQDCH.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_3929-MON.
BRENDA	5.3.1.1. 21018.
Family and domain databases
HAMAP	MF_00147. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000652. Triosephosphate_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
ProDom	PD001005. Triophos_ismrse. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_BACTN

Accession

Primary (citable) accession number: Q8A0U2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)