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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciBTHE:G13PU-8923-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:BT_3945
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829191 – 322Methionyl-tRNA formyltransferaseAdd BLAST322

Proteomic databases

PaxDbiQ8A0S6
PRIDEiQ8A0S6

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_3945

Structurei

3D structure databases

ProteinModelPortaliQ8A0S6
SMRiQ8A0S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
InParanoidiQ8A0S6
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A0S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEDLRIVY MGTPDFAVEA LRQLVEGGYN VVGVITMPDK PAGRGHKIQY
60 70 80 90 100
SPVKQYALEQ NLPLLQPEKL KDEAFVQALR EWKADLQIVV AFRMLPEVVW
110 120 130 140 150
NMPRLGTFNL HASLLPQYRG AAPINWAVIN GDTETGITTF FLQHEIDTGK
160 170 180 190 200
VIQQVRVPIA DTDNVEVVHD KLMILGGKLV LETVDAILND TVKPIAQEDM
210 220 230 240 250
AVVGELRPAP KIFKETCRID WNSPVKKVYD FIRGLSPYPA AWSELVSPEG
260 270 280 290 300
EAVVMKIFES EKIYEAHQLP VGTVVTDGKK YIKVAVPDGF VSVLSLQLPG
310 320
KKRLKTDELL RGFRLSDGYK MN
Length:322
Mass (Da):36,108
Last modified:June 1, 2003 - v1
Checksum:iA1A809FDFDA99419
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO79050.1
RefSeqiNP_812856.1, NC_004663.1
WP_011109030.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO79050; AAO79050; BT_3945
GeneIDi1073048
31615087
KEGGibth:BT_3945
PATRICifig|226186.12.peg.4010

Similar proteinsi

Entry informationi

Entry nameiFMT_BACTN
AccessioniPrimary (citable) accession number: Q8A0S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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