Q8A0N1 (Q8A0N1_BACTN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative alpha-1,2-mannosidase EMBL AAO79095.1

Gene names

Ordered Locus Names:

BT_3990 EMBL AAO79095.1

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) [Reference proteome] [HAMAP] EMBL AAO79095.1

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides › Bacteroides thetaiotaomicron

Protein attributes

Sequence length	755 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Calcium PDB 2WVX PDB 2WZS PDB 2WW3 PDB 2WVZ PDB 2WW0 Metal-binding PDB 2WVX PDB 2WZS PDB 2WW3 PDB 2WVZ PDB 2WW0
Technical term	3D-structure PDB 2WVX PDB 2WZS PDB 2WW3 PDB 2WVZ PDB 2WW0 PDB 2WW1 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro catalytic activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	533	1	Calcium 1 PDB 2WVX
	Metal binding	600	1	Calcium 1; via carbonyl oxygen PDB 2WVX
	Metal binding	601	1	Calcium 2 PDB 2WZS PDB 2WVZ PDB 2WW0
	Metal binding	602	1	Calcium 1 PDB 2WVX
	Metal binding	602	1	Calcium 2 PDB 2WZS PDB 2WVZ PDB 2WW0
	Metal binding	644	1	Calcium 1 PDB 2WVX
	Metal binding	644	1	Calcium 2 PDB 2WZS PDB 2WVZ PDB 2WW0

Sequences

	Sequence		Length	Mass (Da)
	Q8A0N1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 196AA9C076B4823C	FASTA	755	86,633
	10 20 30 40 50 60 MKRLLLIACI LNCTLLSQAK DWTQYVNPLM GSQSTFELST GNTYPAIARP WGMNFWTPQT 70 80 90 100 110 120 GKMGDGWQYT YTANKIRGFK QTHQPSPWIN DYGQFSIMPI VGQPVFDEEK RASWFAHKGE 130 140 150 160 170 180 VATPYYYKVY LAEHDIVTEM TPTERAVLFR FTFPENDHSY VVVDAFDKGS YIKIIPEENK 190 200 210 220 230 240 IIGYTTRNSG GVPENFKNYF IIEFDKPFTY KATVENGNLQ ENVAEQTTDH AGAIIGFKTR 250 260 270 280 290 300 KGEQVNARIA SSFISFEQAA ANMNELGKDN IEQLAQKGKD AWNQVLGKIE VEGGNLDQYR 310 320 330 340 350 360 TFYSCLYRSL LFPRKFYELD ANGQPIHYSP YNGQVLPGYM FTDTGFWDTF RCLFPLLNLM 370 380 390 400 410 420 YPSVNKEMQE GLINTYLESG FFPEWASPGH RGCMVGNNSA SILVDAYMKG VKVDDIKTLY 430 440 450 460 470 480 EGLIHGTENV HPEVSSTGRL GYEYYNKLGY VPYDVKINEN AARTLEYAYD DWCIYRLAKE 490 500 510 520 530 540 LKRPKKEISL FAKRAMNYKN LFDKESKLMR GRNEDGTFQS PFSPLKWGDA FTEGNSWHYT 550 560 570 580 590 600 WSVFHDPQGL IDLMGGKEMF VTMMDSVFAV PPIFDDSYYG QVIHEIREMT VMNMGNYAHG 610 620 630 640 650 660 NQPIQHMIYL YDYAGQPWKA QYWLRQVMDR MYTPGPDGYC GDEDNGQTSA WYVFSALGFY 670 680 690 700 710 720 PVCPGTDEYV MGTPLFKKAT LHFENGNSLV IDAPNNSTEN FYIDSMSFNG ADHTKNYLRH 730 740 750 EDLFKGGTIK VDMSNRPNLN RGTKEEDMPY SFSKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
[2]	"Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont." Zhu Y., Suits M.D., Thompson A.J., Chavan S., Dinev Z., Dumon C., Smith N., Moremen K.W., Xiang Y., Siriwardena A., Williams S.J., Gilbert H.J., Davies G.J. Nat. Chem. Biol. 6:125-132(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 20-755 IN COMPLEX WITH CALCIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE015928 Genomic DNA. Translation: AAO79095.1.

RefSeq

NP_812901.1. NC_004663.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WVX	X-ray	1.90	A/B/C/D	20-755	[»]
2WVZ	X-ray	2.40	A/B/C/D	20-755	[»]
2WW0	X-ray	2.80	A/B/C/D/E/F/G/H	20-755	[»]
2WW1	X-ray	2.25	A/B/C/D	20-755	[»]
2WW3	X-ray	2.10	A/B/C/D/E/F	20-755	[»]
2WZS	X-ray	2.25	A/B/C/D/E/F/G/H	20-755	[»]

ProteinModelPortal

Q8A0N1.

ModBase

Search...

Protein-protein interaction databases

STRING

226186.BT_3990.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAO79095; AAO79095; BT_3990.

GeneID

1075311.

KEGG

bth:BT_3990.

PATRIC

21063014. VBIBacThe70966_4055.

Phylogenomic databases

HOGENOM

HOG000122165.

OMA

QVIHEIR.

ProtClustDB

CLSK823064.

Enzyme and pathway databases

BioCyc

BTHE226186:GJXV-4067-MONOMER.

Family and domain databases

Gene3D

2.70.98.10. 1 hit.

InterPro

IPR008928. 6-hairpin_glycosidase-like.
IPR005887. Alpha_mannosidase.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR012939. Glyco_hydro_92.
[Graphical view]

Pfam

PF07971. Glyco_hydro_92. 1 hit.
[Graphical view]

SUPFAM

SSF48208. Glyco_trans_6hp. 1 hit.

TIGRFAMs

TIGR01180. aman2_put. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q8A0N1.

Entry information

Entry name

Q8A0N1_BACTN

Accession

Primary (citable) accession number: Q8A0N1

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)