Reviewed, UniProtKB/Swiss-Prot Q8A0L8 (SURE_BACTN)

Names and origin

Protein names

Recommended name:
    5'-nucleotidase surE
    EC=3.1.3.5
Alternative name(s):
    Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	BT_4003

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	5'-nucleotidase surE HAMAP MF_00060		PRO_0000111789
Sites
	Metal binding	13	1	Divalent metal cation By similarity
	Metal binding	14	1	Divalent metal cation By similarity
	Metal binding	44	1	Divalent metal cation By similarity
	Metal binding	100	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8A0L8-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: CF226096DE40B251	FASTA	259	28,365
	10 20 30 40 50 60 MESKKPLILV SNDDGVMAKG ISELVKFLRP LGEIVVMAPD SPRSGSGSAL TVTHPVHYQL 70 80 90 100 110 120 VKREVGLTVY KCTGTPTDCI KLALGSVLDR KPDLIVGGIN HGDNSAINVH YSGTMGVVIE 130 140 150 160 170 180 GCLKGIPSIG FSLCNHRPDA DFEPSGPYIR KIAAMILEKG LPPLTCLNVN FPDTPNLKGV 190 200 210 220 230 240 KVCEQAKGCW VNEWVTCPRL DDHNYFWLTG SFTDHELENE NNDHWALENG YVAITPTTVD 250 MTAYGFIDEL NGYCQQLEF

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO79108.1.
RefSeq	NP_812914.1.
3D structure databases
HSSP	HSSP built from PDB template 1J9L based on UniProtKB P96112.
ModBase	Search...
Genome annotation databases
GeneID	1074660.
GenomeReviews	Gene locus BT_4003 in contig AE015928_GR.
KEGG	bth:BT_4003.
NMPDR	fig|226186.1.peg.4001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8A0L8.
OMA	Q8A0L8. SINIPIK.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_4003-MON.
BRENDA	3.1.3.5. 21018.
Family and domain databases
HAMAP	MF_00060. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
ProDom	PD005378. SurE. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00087. surE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_BACTN

Accession

Primary (citable) accession number: Q8A0L8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)