Q8A0L7 (Q8A0L7_BACTN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL AAO79109.1

Gene names

Ordered Locus Names:

BT_4004

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8A0L7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 19F8C4E14BB3B355	FASTA	378	43,054
	10 20 30 40 50 60 MKYYLIVGEA SGDLHASHLM TALKAEDPQA DFRFFGGDLM AAVGGTMVKH YKELAYMGFI 70 80 90 100 110 120 PVLLHLRTIF ANMKRCKEDI VAWNPDVVIL VDYPGFNLNI AKFVHSETQI PVFYYISPKI 130 140 150 160 170 180 WAWKEYRIKN IKRDVDELFS ILPFEVEFYT LKHRYPIHYV GNPTVDEVTA YQKAHPKNPE 190 200 210 220 230 240 AFLADNNLED KPIIALLAGS RKQEIKDNLP DMLKAASAFP DYQLVLAGAP GIAPEYYKQY 250 260 270 280 290 300 VGQAKVKIIF AQTYRLLQHA EVALATSGTA TLETALFRVP QVVCYYTPIG KVVSFLRRHI 310 320 330 340 350 360 LKVKFISLVN LIADREVVKE LVADTMTVGN MQNELKKLIE DQEYKNRMLA EYEYMADRLG 370 PAGAPQHAAR KMLELLKK

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015928 Genomic DNA. Translation: AAO79109.1.
RefSeq	NP_812915.1. NC_004663.1.
3D structure databases
ProteinModelPortal	Q8A0L7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1074643.
GenomeReviews	Gene locus BT_4004 in contig AE015928_GR.
KEGG	bth:BT_4004.
NMPDR	fig|226186.1.peg.4002.
PATRIC	21063044. VBIBacThe70966_4070.
Phylogenomic databases
HOGENOM	HBG584837.
OMA	PDFNLGL.
PhylomeDB	Q8A0L7.
ProtClustDB	CLSK2391382.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8A0L7_BACTN

Accession

Primary (citable) accession number: Q8A0L7

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)