Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Putative haloacid dehalogenase-like hydrolase

Gene

BT_4131

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Magnesium 1Combined sources
Metal bindingi10 – 101Magnesium 1; via carbonyl oxygenCombined sources
Metal bindingi211 – 2111Magnesium 1Combined sources
Metal bindingi219 – 2191Magnesium 2; via carbonyl oxygenCombined sources
Metal bindingi220 – 2201Magnesium 2; via carbonyl oxygenCombined sources
Metal bindingi222 – 2221Magnesium 2; via carbonyl oxygenCombined sources
Metal bindingi240 – 2401Magnesium 2Combined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Keywords - Ligandi

MagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-4209-MONOMER.
SABIO-RKQ8A090.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative haloacid dehalogenase-like hydrolaseImported
Gene namesi
Ordered Locus Names:BT_4131Imported
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)Imported
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8A090.

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_4131.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YMQX-ray1.90A1-261[»]
2RARX-ray1.52A1-261[»]
2RAVX-ray1.07A1-261[»]
2RB5X-ray1.03A1-261[»]
2RBKX-ray1.00A1-261[»]
ProteinModelPortaliQ8A090.
SMRiQ8A090. Positions 1-261.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8A090.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 255251HAD-like_domInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4108HCJ. Bacteria.
COG0561. LUCA.
HOGENOMiHOG000184780.
InParanoidiQ8A090.
KOiK07024.
OMAiDYVRWHE.
OrthoDBiEOG6DRPKW.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR000150. Hypothet_cof.
[Graphical view]
PfamiPF08282. Hydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR00099. Cof-subfamily. 1 hit.
TIGR01484. HAD-SF-IIB. 1 hit.
PROSITEiPS01228. COF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8A090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKALFFDID GTLVSFETHR IPSSTIEALE AAHAKGLKIF IATGRPKAII
60 70 80 90 100
NNLSELQDRN LIDGYITMNG AYCFVGEEVI YKSAIPQEEV KAMAAFCEKK
110 120 130 140 150
GVPCIFVEEH NISVCQPNEM VKKIFYDFLH VNVIPTVSFE EASNKEVIQM
160 170 180 190 200
TPFITEEEEK EVLPSIPTCE IGRWYPAFAD VTAKGDTKQK GIDEIIRHFG
210 220 230 240 250
IKLEETMSFG DGGNDISMLR HAAIGVAMGQ AKEDVKAAAD YVTAPIDEDG
260
ISKAMKHFGI I
Length:261
Mass (Da):28,856
Last modified:June 1, 2003 - v1
Checksum:iC1EED3F8A80733C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO79236.1.
RefSeqiNP_813042.1. NC_004663.1.
WP_008764352.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO79236; AAO79236; BT_4131.
GeneIDi1071784.
KEGGibth:BT_4131.
PATRICi21063302. VBIBacThe70966_4198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO79236.1.
RefSeqiNP_813042.1. NC_004663.1.
WP_008764352.1. NC_004663.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YMQX-ray1.90A1-261[»]
2RARX-ray1.52A1-261[»]
2RAVX-ray1.07A1-261[»]
2RB5X-ray1.03A1-261[»]
2RBKX-ray1.00A1-261[»]
ProteinModelPortaliQ8A090.
SMRiQ8A090. Positions 1-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_4131.

Proteomic databases

PaxDbiQ8A090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO79236; AAO79236; BT_4131.
GeneIDi1071784.
KEGGibth:BT_4131.
PATRICi21063302. VBIBacThe70966_4198.

Phylogenomic databases

eggNOGiENOG4108HCJ. Bacteria.
COG0561. LUCA.
HOGENOMiHOG000184780.
InParanoidiQ8A090.
KOiK07024.
OMAiDYVRWHE.
OrthoDBiEOG6DRPKW.

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-4209-MONOMER.
SABIO-RKQ8A090.

Miscellaneous databases

EvolutionaryTraceiQ8A090.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR000150. Hypothet_cof.
[Graphical view]
PfamiPF08282. Hydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR00099. Cof-subfamily. 1 hit.
TIGR01484. HAD-SF-IIB. 1 hit.
PROSITEiPS01228. COF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482Imported.
  2. "HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131."
    Lu Z., Dunaway-Mariano D., Allen K.N.
    Biochemistry 44:8684-8696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  3. "The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state."
    Lu Z., Dunaway-Mariano D., Allen K.N.
    Proc. Natl. Acad. Sci. U.S.A. 105:5687-5692(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.00 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482Imported.

Entry informationi

Entry nameiQ8A090_BACTN
AccessioniPrimary (citable) accession number: Q8A090
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.