Q8A090 (Q8A090_BACTN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative haloacid dehalogenase-like hydrolase EMBL AAO79236.1

Gene names

Ordered Locus Names:

BT_4131

Organism

Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

Taxonomic identifier

226186 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Magnesium PDB 1YMQ PDB 2RB5 PDB 2RBK PDB 2RAV PDB 2RAR Metal-binding PDB 1YMQ PDB 2RB5 PDB 2RBK PDB 2RAV PDB 2RAR
Molecular function	Hydrolase EMBL AAO79236.1
Technical term	3D-structure PDB 1YMQ PDB 2RB5 PDB 2RBK PDB 2RAV PDB 2RAR Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	8	1	Magnesium PDB 1YMQ PDB 2RB5 PDB 2RBK
	Metal binding	10	1	Magnesium; via carbonyl oxygen PDB 1YMQ PDB 2RB5 PDB 2RBK
	Metal binding	211	1	Magnesium PDB 1YMQ PDB 2RB5 PDB 2RBK

Sequences

	Sequence		Length	Mass (Da)
	Q8A090 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C1EED3F8A80733C2	FASTA	261	28,856
	10 20 30 40 50 60 MTKALFFDID GTLVSFETHR IPSSTIEALE AAHAKGLKIF IATGRPKAII NNLSELQDRN 70 80 90 100 110 120 LIDGYITMNG AYCFVGEEVI YKSAIPQEEV KAMAAFCEKK GVPCIFVEEH NISVCQPNEM 130 140 150 160 170 180 VKKIFYDFLH VNVIPTVSFE EASNKEVIQM TPFITEEEEK EVLPSIPTCE IGRWYPAFAD 190 200 210 220 230 240 VTAKGDTKQK GIDEIIRHFG IKLEETMSFG DGGNDISMLR HAAIGVAMGQ AKEDVKAAAD 250 260 YVTAPIDEDG ISKAMKHFGI I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
[2]	"HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131." Lu Z., Dunaway-Mariano D., Allen K.N. Biochemistry 44:8684-8696(2005) [PubMed: 15952775] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
[3]	"The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state." Lu Z., Dunaway-Mariano D., Allen K.N. Proc. Natl. Acad. Sci. U.S.A. 105:5687-5692(2008) [PubMed: 18398008] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.00 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE015928 Genomic DNA. Translation: AAO79236.1.

RefSeq

NP_813042.1. NC_004663.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YMQ	X-ray	1.90	A	1-261	[»]
2RAR	X-ray	1.52	A	1-261	[»]
2RAV	X-ray	1.07	A	1-261	[»]
2RB5	X-ray	1.03	A	1-261	[»]
2RBK	X-ray	1.00	A	1-261	[»]

ProteinModelPortal

Q8A090.

SMR

Q8A090. Positions 1-261.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1071784.

GenomeReviews

Gene locus BT_4131 in contig AE015928_GR.

KEGG

bth:BT_4131.

NMPDR

fig|226186.1.peg.4129.

PATRIC

21063302. VBIBacThe70966_4198.

Phylogenomic databases

HOGENOM

HBG728500.

OMA

TILATGR.

PhylomeDB

Q8A090.

ProtClustDB

CLSK823801.

Family and domain databases

InterPro

IPR023214. HAD-like_dom.
IPR013200. HAD-SF_hydro-like_3.
IPR006379. HAD-SF_hydro_IIB.
IPR000150. Hypothet_cof.
[Graphical view]

Gene3D

G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.

KO

K07024.

Pfam

PF08282. Hydrolase_3. 1 hit.
[Graphical view]

SUPFAM

SSF56784. HAD-like_dom. 1 hit.

TIGRFAMs

TIGR00099. Cof-subfamily. 1 hit.
TIGR01484. HAD-SF-IIB. 1 hit.

PROSITE

PS01228. COF_1. 1 hit.
PS01229. COF_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8A090_BACTN

Accession

Primary (citable) accession number: Q8A090

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)