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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciBTHE:G13PU-9189-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:BT_4209
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001389451 – 274Orotidine 5'-phosphate decarboxylaseAdd BLAST274

Proteomic databases

PaxDbiQ8A012
PRIDEiQ8A012

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_4209

Structurei

3D structure databases

ProteinModelPortaliQ8A012
SMRiQ8A012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105SKN Bacteria
COG0284 LUCA
HOGENOMiHOG000245747
InParanoidiQ8A012
KOiK01591
OMAiQSAFFER
OrthoDBiPOG091H09O1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8A012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQQLFENI KRKKSFLCVG LDTDIKKIPE HLLKEEDPIF AFNKAIIDAT
60 70 80 90 100
ADLCIAYKPN LAFYESMGVK GWIAFEKTVK YIKENYPDQF IIADAKRGDI
110 120 130 140 150
GNTSAMYART FFEELEIDSV TVAPYMGEDS VTPFLTYEGK WVILLALTSN
160 170 180 190 200
KGSHDFQLTE DANGERLFEK VLRKSQEWAN DERMMYVVGA TQGRAFEDIR
210 220 230 240 250
KIVPNHFLLV PGVGAQGGSL EEVCKYGMNS TCGLIVNSSR GIIYVDKTEK
260 270
FAEAARLAAQ EVQVQMAEQL KAIL
Length:274
Mass (Da):30,880
Last modified:June 1, 2003 - v1
Checksum:iDB4A532D4C38A7BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA Translation: AAO79314.1
RefSeqiNP_813120.1, NC_004663.1
WP_008759883.1, NC_004663.1

Genome annotation databases

EnsemblBacteriaiAAO79314; AAO79314; BT_4209
GeneIDi1073762
31618324
KEGGibth:BT_4209
PATRICifig|226186.12.peg.4276

Entry informationi

Entry nameiPYRF_BACTN
AccessioniPrimary (citable) accession number: Q8A012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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