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Protein

Pyridoxal kinase

Gene

BT_4458

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.SAAS annotation

Pathwayi: pyridoxal 5'-phosphate salvage

This protein is involved in step 1 of the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxal.SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pyridoxal kinase (BT_4458)
This subpathway is part of the pathway pyridoxal 5'-phosphate salvage, which is itself part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxal 5'-phosphate from pyridoxal, the pathway pyridoxal 5'-phosphate salvage and in Cofactor metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-4538-MONOMER.
UniPathwayiUPA01068; UER00298.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal kinaseSAAS annotation (EC:2.7.1.35SAAS annotation)
Gene namesi
Ordered Locus Names:BT_4458Imported
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)Imported
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000001414 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ89ZB9.

Interactioni

Protein-protein interaction databases

STRINGi226186.BT_4458.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MBHX-ray2.00A/B/C/D/E/F1-290[»]
3MBJX-ray2.10A1-290[»]
ProteinModelPortaliQ89ZB9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ89ZB9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 260187Phos_pyr_kinInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pyridoxine kinase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108K05. Bacteria.
COG2240. LUCA.
HOGENOMiHOG000113253.
InParanoidiQ89ZB9.
KOiK00868.
OMAiPIMADKG.
OrthoDBiEOG66F095.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR004625. PyrdxlKinase.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10534. PTHR10534. 1 hit.
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89ZB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYANKVKKIA AVHDLSGMGR VSLTVVIPIL SSMGFQVCPL PTAVLSNHTQ
60 70 80 90 100
YPGFSFLDLT DEMPKIIAEW KKLEVQFDAI YTGYLGSPRQ IQIVSDFIKD
110 120 130 140 150
FRQPDSLIVA DPVLGDNGRL YTNFDMEMVK EMRHLITKAD VITPNLTELF
160 170 180 190 200
YLLDEPYKAD STDEELKEYL RLLSDKGPQV VIITSVPVHD EPHKTSVYAY
210 220 230 240 250
NRQGNRYWKV TCPYLPAHYP GTGDTFTSVI TGSLMQGDSL PMALDRATQF
260 270 280 290
ILQGIRATFG YEYDNREGIL LEKVLHNLDM PIQMASYELI
Length:290
Mass (Da):32,827
Last modified:June 1, 2003 - v1
Checksum:iD522ED7A1C657D9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO79563.1.
RefSeqiNP_813369.1. NC_004663.1.
WP_008764616.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO79563; AAO79563; BT_4458.
GeneIDi1071691.
KEGGibth:BT_4458.
PATRICi21063986. VBIBacThe70966_4539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015928 Genomic DNA. Translation: AAO79563.1.
RefSeqiNP_813369.1. NC_004663.1.
WP_008764616.1. NC_004663.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MBHX-ray2.00A/B/C/D/E/F1-290[»]
3MBJX-ray2.10A1-290[»]
ProteinModelPortaliQ89ZB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_4458.

Proteomic databases

PaxDbiQ89ZB9.

Protocols and materials databases

DNASUi1071691.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO79563; AAO79563; BT_4458.
GeneIDi1071691.
KEGGibth:BT_4458.
PATRICi21063986. VBIBacThe70966_4539.

Phylogenomic databases

eggNOGiENOG4108K05. Bacteria.
COG2240. LUCA.
HOGENOMiHOG000113253.
InParanoidiQ89ZB9.
KOiK00868.
OMAiPIMADKG.
OrthoDBiEOG66F095.

Enzyme and pathway databases

UniPathwayiUPA01068; UER00298.
BioCyciBTHE226186:GJXV-4538-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ89ZB9.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR013749. PM/HMP-P_kinase-1.
IPR004625. PyrdxlKinase.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10534. PTHR10534. 1 hit.
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482Imported.
  3. "Crystal structure of a putative phosphomethylpyrimidine kinase (BT_4458) from BACTEROIDES THETAIOTAOMICRON VPI-5482 at 2.00 A resolution (orthorhombic form with pyridoxal)."
    Joint Center for Structural Genomics (JCSG)
    Submitted (MAR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  4. "Crystal structure of a putative phosphomethylpyrimidine kinase (BT_4458) from BACTEROIDES THETAIOTAOMICRON VPI-5482 at 2.10 A resolution (rhombohedral form)."
    Joint Center for Structural Genomics (JCSG)
    Submitted (MAR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Entry informationi

Entry nameiQ89ZB9_BACTN
AccessioniPrimary (citable) accession number: Q89ZB9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.