Reviewed, UniProtKB/Swiss-Prot Q89YZ6 (GCST_BACTN)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	BT_4584

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity.
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Aminomethyltransferase HAMAP MF_00259		PRO_0000122544

Sequences

	Sequence		Length	Mass (Da)
	Q89YZ6-1 [UniParc]. Last modified May 30, 2003. Version 1. Checksum: C57E87A164F95A89	FASTA	361	39,826
	10 20 30 40 50 60 MKTTPFTEKH IALGAKMHEF AGYNMPIEYS GIIDEHLTVC NAVGVFDVSH MGEFWVKGPQ 70 80 90 100 110 120 ALAFLQKVTS NNVAALVPGK IQYTCFPNEE GGIVDDLLVY CYEPEKYLLV VNAANIEKDW 130 140 150 160 170 180 NWCVSHNTEG AELENSSDNM AQLAVQGPKA ILALQKLTDI DLSAIPYYTF TVGRFAGKEN 190 200 210 220 230 240 VIISNTGYTG AGGFELYFYP DAAEAIWKAV FEAGEEFGIK PVGLGARDTL RLEMGFCLYG 250 260 270 280 290 300 NDLDDKTSPI EAGLGWITKF VEGKEFINRP MLEKQKSEGT TRKLVGFEMI DRGIPRHGYE 310 320 330 340 350 360 LVNEEGEGIG VVTSGTMSPT RKIGIGMGYV KPEYAKVGTE ICIDMRGRKL KAIVVKPPFR K

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO79689.1.
RefSeq	NP_813495.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1073159.
GenomeReviews	Gene locus BT_4584 in contig AE015928_GR.
KEGG	bth:BT_4584.
NMPDR	fig|226186.1.peg.4582.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89YZ6.
OMA	Q89YZ6. VEIRGKW.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_4584-MON.
BRENDA	2.1.2.10. 21018.
Family and domain databases
HAMAP	MF_00259. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BACTN

Accession

Primary (citable) accession number: Q89YZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	May 30, 2003
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)