Reviewed, UniProtKB/Swiss-Prot Q89YZ2 (PTH_BACTN)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase
      Short name=PTH
    EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	BT_4588

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187693

Sequences

	Sequence		Length	Mass (Da)
	Q89YZ2-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7C177DEF62074540	FASTA	189	21,089
	10 20 30 40 50 60 MIKYLIVGLG NIGPEYHETR HNIGFMTVEA LARINNAPPF IDGRYGFTTS FSIKGRQLIL 70 80 90 100 110 120 LKPSTFMNLS GLAVRYWMQK ENIPLENVLI VVDDLALPFG TLRLKGKGSD AGHNGLKHIA 130 140 150 160 170 180 AILGTQNYAR LRFGIGNDFP KGGQIDYVLG HFTDEDRKTM DERLETAGEI IKSFCLAGID ITMNQFNKK

References

[1]

"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015928 Genomic DNA. Translation: AAO79693.1.
RefSeq	NP_813499.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1072118.
GenomeReviews	Gene locus BT_4588 in contig AE015928_GR.
KEGG	bth:BT_4588.
NMPDR	fig|226186.1.peg.4586.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89YZ2.
OMA	IKFKTGG.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_4588-MON.
BRENDA	3.1.1.29. 21018.
Family and domain databases
HAMAP	MF_00083. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
ProDom	PD005324. PeptRNAhydrolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_BACTN

Accession

Primary (citable) accession number: Q89YZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)