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Q89XH1

- HGD_BRADU

UniProt

Q89XH1 - HGD_BRADU

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031Proton acceptorUniRule annotation
Metal bindingi346 – 3461IronUniRule annotation
Metal bindingi352 – 3521IronUniRule annotation
Binding sitei361 – 3611homogentisateUniRule annotation
Metal bindingi382 – 3821IronUniRule annotation
Binding sitei382 – 3821homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-345-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:bll0343
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Homogentisate 1,2-dioxygenasePRO_0000220246Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi224911.bll0343.

Structurei

3D structure databases

ProteinModelPortaliQ89XH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ89XH1.
KOiK00451.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89XH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNINTSPDQI IRSSAQVTPG YMSGFGNSFE TEALPGALPI GRNSPQRCAY
60 70 80 90 100
GLYAEQLSGS PFTAPRGTNE RSWLYRIRPS VKHSGRFEKA DAGLWRSAPC
110 120 130 140 150
HEYDLPIAQM RWDPTPVPKE EVTFVQGVQT MTTAGDVNTQ AGMAAHVYLI
160 170 180 190 200
TKSMVDQHFY NADGELMFVL QQGNLRLVTE FGRIDAEPGE IVVIPRGVKF
210 220 230 240 250
RVEIPNGPAR GYLCENYGGA FTLPERGPIG ANCLANARDF LTPVANYEDK
260 270 280 290 300
DTPTELFVKW GGSLFKTTLP HSPIDVVAWH GNYAPYKYDL RTFSPVGAIG
310 320 330 340 350
FDHPDPSIFT VLTSPSETAG TANIDFVIFP ERWMVADNTF RPPWYHMNIM
360 370 380 390 400
SEFMGLIYGV YDAKPQGFVP GGMSLHNCML PHGPDRDAFE HASNGELKPV
410 420 430 440
KLTGTMAFMF ETRYPQRVTA HAANASTLQD DYADCWKGLE KRFDPNRP
Length:448
Mass (Da):49,780
Last modified:June 6, 2003 - v1
Checksum:iF6DD465E68735D3C
GO

Sequence cautioni

The sequence BAC45608.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC45608.1. Different initiation.
RefSeqiNP_766983.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC45608; BAC45608; BAC45608.
GeneIDi1053162.
KEGGibja:bll0343.
PATRICi21184127. VBIBraJap65052_0342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC45608.1 . Different initiation.
RefSeqi NP_766983.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q89XH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.bll0343.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC45608 ; BAC45608 ; BAC45608 .
GeneIDi 1053162.
KEGGi bja:bll0343.
PATRICi 21184127. VBIBraJap65052_0342.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
InParanoidi Q89XH1.
KOi K00451.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci BJAP224911:GJEJ-345-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiHGD_BRADU
AccessioniPrimary (citable) accession number: Q89XH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 6, 2003
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3