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Q89XH1 (HGD_BRADU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:bll0343
OrganismBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) [Reference proteome] [HAMAP]
Taxonomic identifier224911 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence caution

The sequence BAC45608.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000220246

Sites

Metal binding3461Iron By similarity
Metal binding3521Iron By similarity
Metal binding3821Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q89XH1 [UniParc].

Last modified June 6, 2003. Version 1.
Checksum: F6DD465E68735D3C

FASTA44849,780
        10         20         30         40         50         60 
MNINTSPDQI IRSSAQVTPG YMSGFGNSFE TEALPGALPI GRNSPQRCAY GLYAEQLSGS 

        70         80         90        100        110        120 
PFTAPRGTNE RSWLYRIRPS VKHSGRFEKA DAGLWRSAPC HEYDLPIAQM RWDPTPVPKE 

       130        140        150        160        170        180 
EVTFVQGVQT MTTAGDVNTQ AGMAAHVYLI TKSMVDQHFY NADGELMFVL QQGNLRLVTE 

       190        200        210        220        230        240 
FGRIDAEPGE IVVIPRGVKF RVEIPNGPAR GYLCENYGGA FTLPERGPIG ANCLANARDF 

       250        260        270        280        290        300 
LTPVANYEDK DTPTELFVKW GGSLFKTTLP HSPIDVVAWH GNYAPYKYDL RTFSPVGAIG 

       310        320        330        340        350        360 
FDHPDPSIFT VLTSPSETAG TANIDFVIFP ERWMVADNTF RPPWYHMNIM SEFMGLIYGV 

       370        380        390        400        410        420 
YDAKPQGFVP GGMSLHNCML PHGPDRDAFE HASNGELKPV KLTGTMAFMF ETRYPQRVTA 

       430        440 
HAANASTLQD DYADCWKGLE KRFDPNRP 

« Hide

References

[1]"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110."
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.
DNA Res. 9:189-197(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000040 Genomic DNA. Translation: BAC45608.1. Different initiation.
RefSeqNP_766983.1. NC_004463.1.

3D structure databases

ProteinModelPortalQ89XH1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224911.bll0343.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC45608; BAC45608; BAC45608.
GeneID1053162.
KEGGbja:bll0343.
PATRIC21184127. VBIBraJap65052_0342.

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycBJAP224911:GJEJ-345-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_BRADU
AccessionPrimary (citable) accession number: Q89XH1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 6, 2003
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways