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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi477 – 4826ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-622-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:blr0616
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Topological domaini191 – 825635CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 825825DNA translocase FtsKPRO_0000098242Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi224911.blr0616.

Structurei

3D structure databases

ProteinModelPortaliQ89WR2.
SMRiQ89WR2. Positions 323-736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini457 – 676220FtsKPROSITE-ProRule annotationAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNU. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000010003.
InParanoidiQ89WR2.
KOiK03466.
OMAiQECRLIM.
OrthoDBiPOG091H01S4.
PhylomeDBiQ89WR2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89WR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSAIERVI PLVGHLPPSI REGLARRMRE LAGLGLIALS GLASAALMTW
60 70 80 90 100
SVQDASLSHA TSRPIRNILG YAGAIGADLA MQILGLGAIM LVLTVAVWGW
110 120 130 140 150
RMMTHRPFDR EALRLGSWIL CTVIAAGFVS CWPHGGAWPL PTGLGGVVGD
160 170 180 190 200
ALVRAPAVIF GPPGMIYRTV LGVILFAAMA ATFLIACGLG AREHDDELAE
210 220 230 240 250
IEDDDKPLDE DEESDRGSVS LGWLFHALMS TKARLIWLCG AAYRSLVSSG
260 270 280 290 300
PKTRAVGFSR QEPNLGGGRA APPISPRSED EDYEEEHEEE EDEEEEEEPA
310 320 330 340 350
ARAPRKKAAP KAAAKKSSDK FELPSVSVLA APKAGDRQPL SKAELEANSR
360 370 380 390 400
ALEGVLQDFG VRGEIVKANP GPVVTLYELE PAPGIKSSRV IGLADDIARS
410 420 430 440 450
MSALSARVAV VPGRNAIGIE LPNAHREKVY LRELLVAKET VDTVAKLPLC
460 470 480 490 500
LGKTIGGDPV IIDLARTPHM LIAGTTGSGK SVAINTMILS LVYRLRPDQC
510 520 530 540 550
RLIMVDPKML ELSVYDGIPH LLTPVVTDPK KAVVALKWAV REMEERYKNM
560 570 580 590 600
AKLGVRNIDG YNTRLLELKA KGEEPTRTVH TGFDKETGKA IYEEEKLSLD
610 620 630 640 650
PLPYIVIIVD EMADLMMVAG KDIEGAVQRL AQMARAAGLH VILATQRPSV
660 670 680 690 700
DVITGTIKAN FPTRIAFQVT SKIDSRTILG EMGAEQLLGQ GDMLYMAGGG
710 720 730 740 750
RISRVHGPFA SDDEVEKVVR HLKTQGQPEY LEAVTAEEPT EDEDGGAVFD
760 770 780 790 800
ASGMGADGGG DLFQQAVAIV KRDRKASTSY IQRRLQIGYN RAASLMERME
810 820
LEGIVGPANH AGKREILVEE EDSHM
Length:825
Mass (Da):89,035
Last modified:June 1, 2003 - v1
Checksum:i96F7C679D932B7F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC45881.1.
RefSeqiNP_767256.1. NC_004463.1.
WP_011083444.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC45881; BAC45881; BAC45881.
GeneIDi1053308.
KEGGibja:blr0616.
PATRICi21184718. VBIBraJap65052_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC45881.1.
RefSeqiNP_767256.1. NC_004463.1.
WP_011083444.1. NC_004463.1.

3D structure databases

ProteinModelPortaliQ89WR2.
SMRiQ89WR2. Positions 323-736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.blr0616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC45881; BAC45881; BAC45881.
GeneIDi1053308.
KEGGibja:blr0616.
PATRICi21184718. VBIBraJap65052_0633.

Phylogenomic databases

eggNOGiENOG4105CNU. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000010003.
InParanoidiQ89WR2.
KOiK03466.
OMAiQECRLIM.
OrthoDBiPOG091H01S4.
PhylomeDBiQ89WR2.

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-622-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSK_BRADU
AccessioniPrimary (citable) accession number: Q89WR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.