Reviewed, UniProtKB/Swiss-Prot Q89WK2 (DAPB_BRAJA)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	blr0685

Organism

Bradyrhizobium japonicum [Complete proteome] [HAMAP]

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000141416

Sequences

	Sequence		Length	Mass (Da)
	Q89WK2-1 [UniParc]. Last modified December 15, 2003. Version 2. Checksum: 9A22C74DF0AEC78D	FASTA	271	27,683
	10 20 30 40 50 60 MSDMRLIVAG AGGRMGRALT RAIAESKGAV LAGALEAPGS EMLGKDAGVL AGLPANGIKL 70 80 90 100 110 120 SADLWAMSKE ADGILDFTVP AATIANVAIA AERGIVHVIG TTGLSGSDNA VIKSVTNRAV 130 140 150 160 170 180 VVQSGNMSLG VNLLAAVVKR VAKALDQSFD IEIVETHHRM KIDAPSGTAL MLGQAAAAGR 190 200 210 220 230 240 GISLDEHADR GRDGITGARK PGNIGFASLR GGTAAGDHSV SFLGPFERLT LSHQAEDRML 250 260 270 FAHGALKAAL WAHGKKPGHY SMADVLGLAD I

References

[1]

"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000040 Genomic DNA. Translation: BAC45950.1. Different initiation.
RefSeq	NP_767325.1.
3D structure databases
HSSP	HSSP built from PDB template 1DRW based on UniProtKB P04036.
ModBase	Search...
Genome annotation databases
GeneID	1049266.
GenomeReviews	Gene locus blr0685 in contig BA000040_GR.
KEGG	bja:blr0685.
NMPDR	fig|224911.1.peg.685.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89WK2.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR0685-MON.
BRENDA	1.3.1.26. 280.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. Dihydrodipicolinate_Rdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BRAJA

Accession

Primary (citable) accession number: Q89WK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	September 22, 2009
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)