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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD), Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF), N-(5'-phosphoribosyl)anthranilate isomerase (trpF), N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-753-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:blr0745
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000989231 – 405Tryptophan synthase beta chainAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi224911.blr0745

Structurei

3D structure databases

ProteinModelPortaliQ89WE5
SMRiQ89WE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CG0 Bacteria
COG0133 LUCA
HOGENOMiHOG000161710
InParanoidiQ89WE5
KOiK01696
OMAiHGMKSYF
OrthoDBiPOG091H02JY
PhylomeDBiQ89WE5

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q89WE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIAKPNSYR SGPDERGHFG IFGGRFVAET LMPLILDLEK AYTAAKADPA
60 70 80 90 100
FQAEMNGYLK NYVGRPSPLY FAERLTEHLG GAKIYLKREE LNHTGSHKVN
110 120 130 140 150
NVLGQIMLAR RMGKKRIIAE TGAGQHGVAT ATLCARFGLE CVVYMGAVDV
160 170 180 190 200
ERQQPNVIRM EMLGAKVVPV QSGTRTLKDA MNEALRDWVT NVHNTFYCIG
210 220 230 240 250
TVAGPHPYPT LVRDFQSIIG NETKAQMQEV EGRLPDSLVA CIGGGSNAMG
260 270 280 290 300
LFHPFLDDPS VEIFGVEAAG HGLTQLHAAS IAGGRPGVLH GNRTYLLMDA
310 320 330 340 350
DGQIQDAHSI SAGLDYPGIG PEHSWLHEIG RVNYLSATDD EALAAFQLLS
360 370 380 390 400
KLEGIIPALE PAHAIAKVME LAPKRAKDHL MVVNLSGRGD KDVPQVGDIL

RGKSK
Length:405
Mass (Da):43,862
Last modified:June 1, 2003 - v1
Checksum:iB84FD406C5D55572
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA Translation: BAC46010.1
RefSeqiNP_767385.1, NC_004463.1
WP_011083569.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC46010; BAC46010; BAC46010
GeneIDi1049136
KEGGibja:blr0745
PATRICifig|224911.44.peg.119

Similar proteinsi

Entry informationi

Entry nameiTRPB_BRADU
AccessioniPrimary (citable) accession number: Q89WE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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