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Q89WA4

- TRMB_BRADU

UniProt

Q89WA4 - TRMB_BRADU

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (16 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei67 – 671S-adenosyl-L-methionineUniRule annotation
    Binding sitei92 – 921S-adenosyl-L-methionineUniRule annotation
    Binding sitei119 – 1191S-adenosyl-L-methionineUniRule annotation
    Active sitei141 – 1411By similarity
    Binding sitei141 – 1411S-adenosyl-L-methionineUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation
    Binding sitei177 – 1771SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-796-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:bll0788
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236tRNA (guanine-N(7)-)-methyltransferasePRO_0000171304Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224911.bll0788.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89WA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OrthoDBiEOG6K6VBC.
    PhylomeDBiQ89WA4.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89WA4-1 [UniParc]FASTAAdd to Basket

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    MSERKSDPDR DDSERAFFGR RKGHKLRQHQ AELIDHLLPH LALDIAGEAP    50
    GNACEIFDPA ASDVRLEIGF GGGEHLAAEA QNFATTGFIG CEPYVNGMAK 100
    ILAQIEAGNI ANIRLFAGDA AELLAWLPKA SLSRIDLIHP DPWPKRRHWK 150
    RRFVQDRTIA AMARVLKVGG EFRFVCDIDD YCAWTLSHLA RSADFKWLAE 200
    RADDFRQPWD GYTMTRYGRK AAREGRKAAY LRFRRS 236
    Length:236
    Mass (Da):26,766
    Last modified:June 16, 2003 - v1
    Checksum:i09D1B7A43966F01C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC46053.1.
    RefSeqiNP_767428.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC46053; BAC46053; BAC46053.
    GeneIDi1051109.
    KEGGibja:bll0788.
    PATRICi21185080. VBIBraJap65052_0812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC46053.1 .
    RefSeqi NP_767428.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali Q89WA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.bll0788.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC46053 ; BAC46053 ; BAC46053 .
    GeneIDi 1051109.
    KEGGi bja:bll0788.
    PATRICi 21185080. VBIBraJap65052_0812.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OrthoDBi EOG6K6VBC.
    PhylomeDBi Q89WA4.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci BJAP224911:GJEJ-796-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiTRMB_BRADU
    AccessioniPrimary (citable) accession number: Q89WA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3