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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei67S-adenosyl-L-methionineUniRule annotation1
Binding sitei92S-adenosyl-L-methionineUniRule annotation1
Binding sitei119S-adenosyl-L-methionineUniRule annotation1
Active sitei141By similarity1
Binding sitei141S-adenosyl-L-methionineUniRule annotation1
Binding sitei145SubstrateUniRule annotation1
Binding sitei177SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-796-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:bll0788
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001713041 – 236tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST236

Proteomic databases

PRIDEiQ89WA4

Interactioni

Protein-protein interaction databases

STRINGi224911.bll0788

Structurei

3D structure databases

ProteinModelPortaliQ89WA4
SMRiQ89WA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000073969
InParanoidiQ89WA4
KOiK03439
OMAiPDPWHKS
OrthoDBiPOG091H015P
PhylomeDBiQ89WA4

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q89WA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERKSDPDR DDSERAFFGR RKGHKLRQHQ AELIDHLLPH LALDIAGEAP
60 70 80 90 100
GNACEIFDPA ASDVRLEIGF GGGEHLAAEA QNFATTGFIG CEPYVNGMAK
110 120 130 140 150
ILAQIEAGNI ANIRLFAGDA AELLAWLPKA SLSRIDLIHP DPWPKRRHWK
160 170 180 190 200
RRFVQDRTIA AMARVLKVGG EFRFVCDIDD YCAWTLSHLA RSADFKWLAE
210 220 230
RADDFRQPWD GYTMTRYGRK AAREGRKAAY LRFRRS
Length:236
Mass (Da):26,766
Last modified:June 16, 2003 - v1
Checksum:i09D1B7A43966F01C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA Translation: BAC46053.1
RefSeqiNP_767428.1, NC_004463.1
WP_011083610.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC46053; BAC46053; BAC46053
GeneIDi1051109
KEGGibja:bll0788
PATRICifig|224911.44.peg.163

Similar proteinsi

Entry informationi

Entry nameiTRMB_BRADU
AccessioniPrimary (citable) accession number: Q89WA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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