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Q89VT5

- MTAP_BRADU

UniProt

Q89VT5 - MTAP_BRADU

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121PhosphateUniRule annotation
Sitei167 – 1671Important for substrate specificityUniRule annotation
Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation
Binding sitei186 – 1861PhosphateUniRule annotation
Sitei222 – 2221Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-969-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:blr0960
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291S-methyl-5'-thioadenosine phosphorylasePRO_0000415090Add
BLAST

Proteomic databases

PRIDEiQ89VT5.

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi224911.blr0960.

Structurei

3D structure databases

ProteinModelPortaliQ89VT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Phosphate bindingUniRule annotation
Regioni87 – 882Phosphate bindingUniRule annotation
Regioni209 – 2113Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228986.
InParanoidiQ89VT5.
KOiK00772.
OrthoDBiEOG6KHFXC.
PhylomeDBiQ89VT5.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89VT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQAVLGIIG GSGIYDLPGL EGAHEEVIKS PWGEPSAPLR RGTIAGLPIV
60 70 80 90 100
FLPRHDKGHR LSPSDINYRA NIDVLKRAGV TDLISLSACG SFKEEMPPGT
110 120 130 140 150
FVLVDQFVDR THKRESSFFG RGCVAHVSMA HPVSPRLRIH LAAAAEAEGI
160 170 180 190 200
AIARGGTYVC MEGPQFSTYA ESMTYKTSGY SVIGMTNMPE AKLAREAEIC
210 220 230 240 250
YATVAMVTDF DCWHPDHDAV TVQDIIRVLT SNADKAKALV ARLAKDFPRE
260 270 280 290
HEPCPIGSDR ALDTALITAP EARDPELLKK LDAVAGRVLR G
Length:291
Mass (Da):31,461
Last modified:June 1, 2003 - v1
Checksum:i4C5769311BFC605E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC46225.1.
RefSeqiNP_767600.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC46225; BAC46225; BAC46225.
GeneIDi1048928.
KEGGibja:blr0960.
PATRICi21185422. VBIBraJap65052_0982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC46225.1 .
RefSeqi NP_767600.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q89VT5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.blr0960.

Proteomic databases

PRIDEi Q89VT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC46225 ; BAC46225 ; BAC46225 .
GeneIDi 1048928.
KEGGi bja:blr0960.
PATRICi 21185422. VBIBraJap65052_0982.

Phylogenomic databases

HOGENOMi HOG000228986.
InParanoidi Q89VT5.
KOi K00772.
OrthoDBi EOG6KHFXC.
PhylomeDBi Q89VT5.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci BJAP224911:GJEJ-969-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiMTAP_BRADU
AccessioniPrimary (citable) accession number: Q89VT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3