Q89UU4 (KHSE_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	blr1315

Organism

Bradyrhizobium japonicum

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Homoserine kinase HAMAP MF_00301		PRO_0000172185

Sequences

	Sequence		Length	Mass (Da)
	Q89UU4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E141F9F97F66CF79	FASTA	327	35,819
	10 20 30 40 50 60 MAVYTDVAAD ELADFLSQYD LGELLSYKGI AEGVENSNFL LHTTKGSFIL TLYEKRVAKN 70 80 90 100 110 120 DLPFFLALMT HLAEHGVNCP LPVKGRDGEA LRELSGRPAA IITFLEGVWP RKPNAAHCAG 130 140 150 160 170 180 VGEGLARMHL AGANFAIRRA NALSVAGWRP LFDAAASRAD EVQPGLRAFL AAELDYLASG 190 200 210 220 230 240 VWPTNLPEGV IHADLFNDNV FFLGDKLSGI IDFTFACNDM LAYDVAICLN AWCFEPDHSF 250 260 270 280 290 300 NVTKARAFLN AYGRVRKLSE AEEAALPLLA RGAAIRFLLT RLVDWLNVPP GALVRPKDPL 310 320 EYVRKLRFHQ SVSSVRDYGL MPSGLVA

References

[1]

"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000040 Genomic DNA. Translation: BAC46580.1.
RefSeq	NP_767955.1. NC_004463.1.
3D structure databases
ProteinModelPortal	Q89UU4.
SMR	Q89UU4. Positions 5-320.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1049260.
GenomeReviews	Gene locus blr1315 in contig BA000040_GR.
KEGG	bja:blr1315.
NMPDR	fig|224911.1.peg.1315.
PATRIC	21186182. VBIBraJap65052_1359.
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR1315-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BRAJA

Accession

Primary (citable) accession number: Q89UU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program