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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-1440-MONOMER
UniPathwayiUPA00030
UPA00358; UER00476

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotation
Ordered Locus Names:bll1422
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003700081 – 2463-deoxy-manno-octulosonate cytidylyltransferaseAdd BLAST246

Proteomic databases

PRIDEiQ89UJ4

Interactioni

Protein-protein interaction databases

STRINGi224911.bll1422

Structurei

3D structure databases

ProteinModelPortaliQ89UJ4
SMRiQ89UJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CET Bacteria
COG1212 LUCA
HOGENOMiHOG000007602
InParanoidiQ89UJ4
KOiK00979
OMAiNSGTERC
OrthoDBiPOG091H00UN
PhylomeDBiQ89UJ4

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit

Sequencei

Sequence statusi: Complete.

Q89UJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDPRILVLI PARMAATRLP GKPLADIAGL PMIVHVLRRA EAAGIGRVAV
60 70 80 90 100
ATDTPEIAAV VAAHGGEAVM TRTTHPSGSD RIHEAMQKLD PEGKAEIVIN
110 120 130 140 150
LQGDFPTITP QTIREVLPPF ADPAVDIVTL ASQIHTEEED LAPSVVKAVG
160 170 180 190 200
SPIGPRRLRA LYFTRATAPY GNGPRYHHIG LYAYRRAALE RFVSLPPSPL
210 220 230 240
ELQESLEQLR AVEAGMRIDI MIVDSVPRGV DTPPDLETAR SILSKS
Length:246
Mass (Da):26,513
Last modified:June 1, 2003 - v1
Checksum:iB64BC9310071E130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA Translation: BAC46687.1
RefSeqiNP_768062.1, NC_004463.1
WP_011084239.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC46687; BAC46687; BAC46687
GeneIDi1055172
KEGGibja:bll1422
PATRICifig|224911.44.peg.850

Similar proteinsi

Entry informationi

Entry nameiKDSB_BRADU
AccessioniPrimary (citable) accession number: Q89UJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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