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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-2349-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:bll2327
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_1000146832Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224911.bll2327.

Structurei

3D structure databases

ProteinModelPortaliQ89SS3.
SMRiQ89SS3. Positions 1-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
InParanoidiQ89SS3.
KOiK00763.
OrthoDBiEOG6X10XB.
PhylomeDBiQ89SS3.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89SS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTDIASRT YNHSWRLDPI IRSLLDTDFY KLLMLQMIRE DYSNQQVTFS
60 70 80 90 100
VINRSRHVRL AEIIDEGELR AQLDHARTIR FTKKELIWLA GNTFYGKTHM
110 120 130 140 150
FSADFIRWLA EFRLPEYELR KVEGQYELHF HGPWTHTTMW EIPALAILNE
160 170 180 190 200
LRSRAAIKGR GRFELDVLYA RAKAKLWTKV ERLRKLENLR LSDFGTRRRH
210 220 230 240 250
GFLWQRWCVE AVKEGLGPSF IGTSNVLLAM DNDLEAIGTN AHELPMVAAG
260 270 280 290 300
LAKDDEELRW APYRILDQWR QTYGGNLLIA LPDAFGTKAF LRDAPEWVAD
310 320 330 340 350
WTGFRPDSAP PIQAGEEIIA WWEKKGRNPR DKLLVFSDAM DVGSIEETYH
360 370 380 390 400
HFTGRVRLSF GWGTNLTNDF VGCAPDGSFN LDPISLVCKV SSVDGHPAVK
410 420 430
LSDNPEKATG LPSEIERYLR VFGDVGRVRK PVLV
Length:434
Mass (Da):49,902
Last modified:June 1, 2003 - v1
Checksum:i8EC682BBC4396356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC47592.1.
RefSeqiNP_768967.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC47592; BAC47592; BAC47592.
GeneIDi1050912.
KEGGibja:bll2327.
PATRICi21187996. VBIBraJap65052_2258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC47592.1.
RefSeqiNP_768967.1. NC_004463.1.

3D structure databases

ProteinModelPortaliQ89SS3.
SMRiQ89SS3. Positions 1-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.bll2327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC47592; BAC47592; BAC47592.
GeneIDi1050912.
KEGGibja:bll2327.
PATRICi21187996. VBIBraJap65052_2258.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
InParanoidiQ89SS3.
KOiK00763.
OrthoDBiEOG6X10XB.
PhylomeDBiQ89SS3.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BioCyciBJAP224911:GJEJ-2349-MONOMER.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiPNCB_BRADU
AccessioniPrimary (citable) accession number: Q89SS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.