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Q89SK1 (DCUP_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:bll2399
OrganismBradyrhizobium japonicum
Taxonomic identifier375 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm Probable HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000187588

Regions

Region27 – 315Substrate binding By similarity

Sites

Binding site461Substrate By similarity
Binding site771Substrate By similarity
Binding site1531Substrate By similarity
Binding site2081Substrate By similarity
Binding site3241Substrate By similarity
Site771Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q89SK1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E0B52747C44AC24E

FASTA34437,346
        10         20         30         40         50         60 
MPQSATKPFI DVLSGQRQAI PPMWMMRQAG RYLPEYREVR AKAGGFLDLC FNPELAAEVT 

        70         80         90        100        110        120 
LQPIRRFGFD AAIIFSDILV IPYALGRSVR FEVGEGPRLE PLDDPAKVAT LAPRADFGKL 

       130        140        150        160        170        180 
APVFDALKIV RGALDPKTAL IGFCGAPWTV ATYMVAGHGT PDQAPARMMA YRHPDAFAKI 

       190        200        210        220        230        240 
IDVLVDNSIE YLLAQLAAGA NALQIFDTWA GVLPPAEFAR WSVEPTRRIV EGVRAKVPDA 

       250        260        270        280        290        300 
KIIGFPRGAG AQLPGYVEAT GVNGVSIDWT AEPAFIRERV QSRVAVQGNL DPLVLITGGA 

       310        320        330        340 
ALDRAVDNVL ANFAQGRFIF NLGHGIQPET PIAHVEQMLK RVRG

« Hide

References

[1]"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110."
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.
DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USDA 110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000040 Genomic DNA. Translation: BAC47664.1.
RefSeqNP_769039.1. NC_004463.1.

3D structure databases

ProteinModelPortalQ89SK1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1050589.
GenomeReviewsGene locus bll2399 in contig BA000040_GR.
KEGGbja:bll2399.
NMPDRfig|224911.1.peg.2399.
PATRIC21188160. VBIBraJap65052_2340.

Phylogenomic databases

HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBQ89SK1.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycBJAP224911:BLL2399-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_BRAJA
AccessionPrimary (citable) accession number: Q89SK1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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