Reviewed, UniProtKB/Swiss-Prot Q89SB5 (APT_BRAJA)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase
      Short name=APRT
    EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	blr2490

Organism

Bradyrhizobium japonicum [Complete proteome] [HAMAP]

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00004
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_0000149363

Sequences

	Sequence		Length	Mass (Da)
	Q89SB5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A7B600E0D869A61D	FASTA	179	19,406
	10 20 30 40 50 60 MTFDHDLKAS VRTIPDYPKP GIMFRDITTL LADARAFRRA VDELVNPWAG NKIDKVAGME 70 80 90 100 110 120 ARGFIIGGAV AHQLSAGFVP IRKKGKLPHT TVRIAYSLEY GIDEMEMHVD AIQPGERVIL 130 140 150 160 170 VDDLIATGGT AEGAVKLLRQ IGANVVAACF IIDLPELGGA AKLRAMDVPV RTLMTFEGH

References

[1]

"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000040 Genomic DNA. Translation: BAC47755.1.
RefSeq	NP_769130.1.
3D structure databases
HSSP	HSSP built from PDB template 1G2P based on UniProtKB P49435.
ModBase	Search...
Genome annotation databases
GeneID	1050398.
GenomeReviews	Gene locus blr2490 in contig BA000040_GR.
KEGG	bja:blr2490.
NMPDR	fig|224911.1.peg.2490.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89SB5.
OMA	KPGKLPA.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR2490-MON.
BRENDA	2.4.2.7. 280.
Family and domain databases
HAMAP	MF_00004. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_BRAJA

Accession

Primary (citable) accession number: Q89SB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)