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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051Proton acceptorUniRule annotation
Binding sitei123 – 1231SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-3779-MONOMER.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:blr3755
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Ribose-5-phosphate isomerase APRO_0000158395Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224911.blr3755.

Structurei

3D structure databases

ProteinModelPortaliQ89NS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 314Substrate bindingUniRule annotation
Regioni83 – 864Substrate bindingUniRule annotation
Regioni96 – 994Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
InParanoidiQ89NS9.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.
PhylomeDBiQ89NS9.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89NS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMDQLKRQA AARALEEVRD GMQLGLGTGS TAKHFVELLG ERVAAGLKVI
60 70 80 90 100
GVPTSEATRL DATRCGVPLT TLDEIDHLDI TVDGADEIDP ELNLIKGGGG
110 120 130 140 150
ALLREKIVAA ASDRMIVIAD DTKWVPTLGR FPLPIEVIPF GLGATRRAIE
160 170 180 190 200
TAFAQCGVSG QMAVRKAKGG DKDGHVFVTD GGHWILDAQL GRIVDPPSLA
210 220 230 240
KALSAIPGVV EHGLFIGLAS SAVLAGGEGI RVIERRKPKG D
Length:241
Mass (Da):25,308
Last modified:June 1, 2003 - v1
Checksum:i4348283F4F3D2A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC49020.1.
RefSeqiNP_770395.1. NC_004463.1.
WP_011086536.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC49020; BAC49020; BAC49020.
GeneIDi1052707.
KEGGibja:blr3755.
PATRICi21190965. VBIBraJap65052_3740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC49020.1.
RefSeqiNP_770395.1. NC_004463.1.
WP_011086536.1. NC_004463.1.

3D structure databases

ProteinModelPortaliQ89NS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.blr3755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC49020; BAC49020; BAC49020.
GeneIDi1052707.
KEGGibja:blr3755.
PATRICi21190965. VBIBraJap65052_3740.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
InParanoidiQ89NS9.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.
PhylomeDBiQ89NS9.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BioCyciBJAP224911:GJEJ-3779-MONOMER.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_BRADU
AccessioniPrimary (citable) accession number: Q89NS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.