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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

pdxA2

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

D-threonate 4-phosphate + NAD+ = dihydroxyacetone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Binding sitei139SubstrateBy similarity1
Metal bindingi168Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi212Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi267Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei275SubstrateBy similarity1
Binding sitei295SubstrateBy similarity1
Binding sitei304SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.-By similarity)
Gene namesi
Name:pdxA2
Ordered Locus Names:blr3887
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001887981 – 345Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST345

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224911.blr3887.

Structurei

3D structure databases

ProteinModelPortaliQ89NF3.
SMRiQ89NF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CEZ. Bacteria.
COG1995. LUCA.
HOGENOMiHOG000221593.
InParanoidiQ89NF3.
KOiK00097.
OMAiGHLYPGH.
OrthoDBiPOG091H03XD.
PhylomeDBiQ89NF3.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89NF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRHLAITM GDPAGIGPEI IVKACLGLKG RIATGDLRLL IIGSGAALDG
60 70 80 90 100
AKAALGTDVA IPQVSADDRE WPNLCYLQAD AEGDPIKPGV LSADGGRFAY
110 120 130 140 150
KAIEQGVRLT QAGRTAAIVT APLNKEALNK AGYHFPGHTE MLAHLTGVRG
160 170 180 190 200
SVMLLAHGNM RVSHVSTHVA LEDVPKRLTP ERLRMVIDLT NDALRRLGIA
210 220 230 240 250
KPKIAVAALN PHAGEGGLFG RQDIDVSAPT IAKAVADGLD VIGPVPGDTI
260 270 280 290 300
FVKLRAGQFD AAVAMYHDQG HIPVKLLGFQ VDPATGRWQE LSGVNITLGL
310 320 330 340
PIIRTSVDHG TAFDIAGKGI ANEHSLIEAI DYAERLAAGA SASKS
Length:345
Mass (Da):36,065
Last modified:June 1, 2003 - v1
Checksum:iC67EB244DD7470A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC49152.1.
RefSeqiNP_770527.1. NC_004463.1.
WP_011086666.1. NZ_CP011360.1.

Genome annotation databases

EnsemblBacteriaiBAC49152; BAC49152; BAC49152.
GeneIDi1053741.
KEGGibja:blr3887.
PATRICifig|224911.44.peg.3574.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPDXA2_BRADU
AccessioniPrimary (citable) accession number: Q89NF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families