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Q89NA7

- GLSA1_BRADU

UniProt

Q89NA7 - GLSA1_BRADU

Protein

Glutaminase 1

Gene

glsA1

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei75 – 751SubstrateBy similarity
    Binding sitei124 – 1241SubstrateBy similarity
    Binding sitei168 – 1681SubstrateBy similarity
    Binding sitei175 – 1751SubstrateBy similarity
    Binding sitei199 – 1991SubstrateBy similarity
    Binding sitei251 – 2511SubstrateBy similarity
    Binding sitei269 – 2691Substrate; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi480 – 595116cNMPAdd
    BLAST

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-3960-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminase 1 (EC:3.5.1.2)
    Gene namesi
    Name:glsA1
    Ordered Locus Names:bll3935
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 613613Glutaminase 1PRO_0000110597Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi224911.bll3935.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89NA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini345 – 457113STASAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 315283GlutaminaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutaminase family.Curated
    Contains 1 STAS domain.Curated

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OrthoDBiEOG6N94BK.
    PhylomeDBiQ89NA7.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    3.30.750.24. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR015868. Glutaminase.
    IPR014710. RmlC-like_jellyroll.
    IPR002645. STAS_dom.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF00027. cNMP_binding. 1 hit.
    PF04960. Glutaminase. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF52091. SSF52091. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89NA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPPPASAWT RSKPPLLRFL DTCLNEFSAE TSGAVADYIP ELGNADPAYF    50
    GISLATLDGH VYEVGDSRVP FTIQSMSKPF VFALALDLLG AGRVESAIGV 100
    EPSGDPFNSI RLNSDNHPFN PMVNAGAIAC TGLIYDSKGA EAFEQIRLAL 150
    SRFAGRDLAV DEAVYSSESQ TGDRNRAIGY LLKTNAVISD NVAAVLDVYF 200
    RQCAVLVTAR DIAVMAATLA NRGINPVTGE QVMSAYAISR TLSVMTSSGM 250
    YDYAGEWIYR IGIPAKSGVG GGILAALPAR LGLGSYSPKL DKHGNSVRGI 300
    KVCEALSSHY DLHMLNRSDD ARNAVIADYD IGKSPSRRVR RAQEREILAA 350
    HEQEVRIIEL VGTLSLSAVD YVSRRLAGRP RPQFVIFDLH RVTSTTRAGA 400
    RLVAEAFEEL AALNVTVVLS GVRRASKEWN TLREWTAELK NVRDFYLLDT 450
    AIEWAEDQIV YRYGGSIDFH ETTELAEQPL LEGLSADELA ELGAICTIRT 500
    YQSGAKILTT GDPADALFFL RSGAVHVTLP DGVRLATLTA GMAFGEMALL 550
    EQTRSADVFA DMAATAFEAP LKDFERFREQ HPRASERIMR NLAQLLADRL 600
    IVANAKVDIL TST 613
    Length:613
    Mass (Da):66,635
    Last modified:June 1, 2003 - v1
    Checksum:i2F7F6A35D48DA118
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC49200.1.
    RefSeqiNP_770575.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC49200; BAC49200; BAC49200.
    GeneIDi1053915.
    KEGGibja:bll3935.
    PATRICi21191372. VBIBraJap65052_3942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC49200.1 .
    RefSeqi NP_770575.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali Q89NA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.bll3935.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC49200 ; BAC49200 ; BAC49200 .
    GeneIDi 1053915.
    KEGGi bja:bll3935.
    PATRICi 21191372. VBIBraJap65052_3942.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OrthoDBi EOG6N94BK.
    PhylomeDBi Q89NA7.

    Enzyme and pathway databases

    BioCyci BJAP224911:GJEJ-3960-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    3.30.750.24. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR015868. Glutaminase.
    IPR014710. RmlC-like_jellyroll.
    IPR002645. STAS_dom.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF00027. cNMP_binding. 1 hit.
    PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF52091. SSF52091. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiGLSA1_BRADU
    AccessioniPrimary (citable) accession number: Q89NA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3