Reviewed, UniProtKB/Swiss-Prot Q89L55 (COAD_BRAJA)

Names and origin

Protein names

Recommended name:
    Phosphopantetheine adenylyltransferase
    EC=2.7.7.3
Alternative name(s):
    Pantetheine-phosphate adenylyltransferase
      Short name=PPAT
    Dephospho-CoA pyrophosphorylase

Gene names

Name:	coaD
Ordered Locus Names:	bll4693

Organism

Bradyrhizobium japonicum [Complete proteome] [HAMAP]

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity.
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the bacterial coaD family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Phosphopantetheine adenylyltransferase HAMAP MF_00151		PRO_0000156181

Sequences

	Sequence		Length	Mass (Da)
	Q89L55-1 [UniParc]. Last modified June 6, 2003. Version 1. Checksum: B741021CBE3E60E0	FASTA	165	17,652
	10 20 30 40 50 60 MPRIAFYPGS FDPITNGHLD VVRHAVPLCD RLVVAIGVHP GKKPLFSTEE RLRMLEDVCG 70 80 90 100 110 120 PVATQAGCVL EAVTFDDLSV TAARKHGATI MIRGLRDGTD LDYEMQLAGM NEAMAPEVHT 130 140 150 160 VFLPASPMVR PITATLVRQI AGMGGDVSTF VPPLVASLLK AKFAG

References

[1]

"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000040 Genomic DNA. Translation: BAC49958.1.
RefSeq	NP_771333.1.
3D structure databases
HSSP	HSSP built from PDB template 1GN8 based on UniProtKB P23875.
ModBase	Search...
Genome annotation databases
GeneID	1052363.
GenomeReviews	Gene locus bll4693 in contig BA000040_GR.
KEGG	bja:bll4693.
NMPDR	fig|224911.1.peg.4693.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89L55.
OMA	AMSDFEY.
Enzyme and pathway databases
BioCyc	BJAP224911:BLL4693-MON.
BRENDA	2.7.7.3. 280.
Family and domain databases
HAMAP	MF_00151. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. coaD_prev_kdtB. 1 hit. TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAD_BRAJA

Accession

Primary (citable) accession number: Q89L55

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	June 6, 2003
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)