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Q89KX1

- Q89KX1_BRADU

UniProt

Q89KX1 - Q89KX1_BRADU

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

bll4779

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyruvate metabolic process Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-4812-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Ordered Locus Names:bll4779Imported
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)Imported
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi224911.bll4779.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89KX1.
    SMRiQ89KX1. Positions 3-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000281566.
    KOiK00627.
    OrthoDBiEOG610413.
    PhylomeDBiQ89KX1.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89KX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPINILMPAL SPTMEKGNLA KWLKKEGDKV KSGDVIAEIE TDKATMEVEA    50
    IDEGTIAKIL VPEGTQDVPV NDVIAVLAGE GEDVKAAGAA KPSASAAPPK 100
    ATDAPAAAPA PATAPAAPKA APPPAAAPAP QAAAPAAQSN GHGGRVFSSP 150
    LARRLAKDAG IDVSMVTGTG PHGRVVARDV EQAKSGKGLK APAAAPSSAP 200
    SIAPTMSDKQ ILSLFEPGSY DIVPHDGMRR TIAQRLTASI QNVPHFYLTI 250
    DCDIGKLLAA REEINAAAPK DKEKKPLYKI SVNDFVIKAM AVALQKIPNC 300
    NVSWTESGMV KHHHSDVGVA VAMPGGLITP IIRKAETKTL STISNEMKDF 350
    AARARSRKLK PEEYQGGTTA VSNLGMYGIS HFTAVINPPH ATILAVGTSE 400
    ERPVVRNGKI EIAHMMSVTL SCDHRAIDGA LGAELIGAFK QLIENPVMMM 450
    V 451
    Length:451
    Mass (Da):47,042
    Last modified:June 1, 2003 - v1
    Checksum:iBFF05B24465E1F85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC50044.1.
    RefSeqiNP_771419.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC50044; BAC50044; BAC50044.
    GeneIDi1052251.
    KEGGibja:bll4779.
    PATRICi21193212. VBIBraJap65052_4855.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC50044.1 .
    RefSeqi NP_771419.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali Q89KX1.
    SMRi Q89KX1. Positions 3-86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.bll4779.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC50044 ; BAC50044 ; BAC50044 .
    GeneIDi 1052251.
    KEGGi bja:bll4779.
    PATRICi 21193212. VBIBraJap65052_4855.

    Phylogenomic databases

    HOGENOMi HOG000281566.
    KOi K00627.
    OrthoDBi EOG610413.
    PhylomeDBi Q89KX1.

    Enzyme and pathway databases

    BioCyci BJAP224911:GJEJ-4812-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110Imported.

    Entry informationi

    Entry nameiQ89KX1_BRADU
    AccessioniPrimary (citable) accession number: Q89KX1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3