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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

bll4779

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-4811-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:bll4779Imported
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)Imported
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi224911.bll4779

Structurei

3D structure databases

ProteinModelPortaliQ89KX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini147 – 184Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S Bacteria
COG0508 LUCA
HOGENOMiHOG000281566
InParanoidiQ89KX1
KOiK00627
OMAiSWRLGCD
OrthoDBiPOG091H0NG1
PhylomeDBiQ89KX1

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q89KX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINILMPAL SPTMEKGNLA KWLKKEGDKV KSGDVIAEIE TDKATMEVEA
60 70 80 90 100
IDEGTIAKIL VPEGTQDVPV NDVIAVLAGE GEDVKAAGAA KPSASAAPPK
110 120 130 140 150
ATDAPAAAPA PATAPAAPKA APPPAAAPAP QAAAPAAQSN GHGGRVFSSP
160 170 180 190 200
LARRLAKDAG IDVSMVTGTG PHGRVVARDV EQAKSGKGLK APAAAPSSAP
210 220 230 240 250
SIAPTMSDKQ ILSLFEPGSY DIVPHDGMRR TIAQRLTASI QNVPHFYLTI
260 270 280 290 300
DCDIGKLLAA REEINAAAPK DKEKKPLYKI SVNDFVIKAM AVALQKIPNC
310 320 330 340 350
NVSWTESGMV KHHHSDVGVA VAMPGGLITP IIRKAETKTL STISNEMKDF
360 370 380 390 400
AARARSRKLK PEEYQGGTTA VSNLGMYGIS HFTAVINPPH ATILAVGTSE
410 420 430 440 450
ERPVVRNGKI EIAHMMSVTL SCDHRAIDGA LGAELIGAFK QLIENPVMMM

V
Length:451
Mass (Da):47,042
Last modified:June 1, 2003 - v1
Checksum:iBFF05B24465E1F85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA Translation: BAC50044.1
RefSeqiNP_771419.1, NC_004463.1
WP_011087547.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC50044; BAC50044; BAC50044
GeneIDi1052251
KEGGibja:bll4779
PATRICifig|224911.44.peg.4617

Similar proteinsi

Entry informationi

Entry nameiQ89KX1_BRADU
AccessioniPrimary (citable) accession number: Q89KX1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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