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Q89KX1

- Q89KX1_BRADU

UniProt

Q89KX1 - Q89KX1_BRADU

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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

bll4779

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently.
Binds 2 lipoyl cofactors covalently.
Binds 3 lipoyl cofactors covalently.

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-4812-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:bll4779Imported
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)Imported
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi224911.bll4779.

Structurei

3D structure databases

ProteinModelPortaliQ89KX1.
SMRiQ89KX1. Positions 3-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281566.
InParanoidiQ89KX1.
KOiK00627.
OrthoDBiEOG610413.
PhylomeDBiQ89KX1.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89KX1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPINILMPAL SPTMEKGNLA KWLKKEGDKV KSGDVIAEIE TDKATMEVEA
60 70 80 90 100
IDEGTIAKIL VPEGTQDVPV NDVIAVLAGE GEDVKAAGAA KPSASAAPPK
110 120 130 140 150
ATDAPAAAPA PATAPAAPKA APPPAAAPAP QAAAPAAQSN GHGGRVFSSP
160 170 180 190 200
LARRLAKDAG IDVSMVTGTG PHGRVVARDV EQAKSGKGLK APAAAPSSAP
210 220 230 240 250
SIAPTMSDKQ ILSLFEPGSY DIVPHDGMRR TIAQRLTASI QNVPHFYLTI
260 270 280 290 300
DCDIGKLLAA REEINAAAPK DKEKKPLYKI SVNDFVIKAM AVALQKIPNC
310 320 330 340 350
NVSWTESGMV KHHHSDVGVA VAMPGGLITP IIRKAETKTL STISNEMKDF
360 370 380 390 400
AARARSRKLK PEEYQGGTTA VSNLGMYGIS HFTAVINPPH ATILAVGTSE
410 420 430 440 450
ERPVVRNGKI EIAHMMSVTL SCDHRAIDGA LGAELIGAFK QLIENPVMMM

V
Length:451
Mass (Da):47,042
Last modified:June 1, 2003 - v1
Checksum:iBFF05B24465E1F85
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC50044.1.
RefSeqiNP_771419.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC50044; BAC50044; BAC50044.
GeneIDi1052251.
KEGGibja:bll4779.
PATRICi21193212. VBIBraJap65052_4855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC50044.1 .
RefSeqi NP_771419.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q89KX1.
SMRi Q89KX1. Positions 3-86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.bll4779.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC50044 ; BAC50044 ; BAC50044 .
GeneIDi 1052251.
KEGGi bja:bll4779.
PATRICi 21193212. VBIBraJap65052_4855.

Phylogenomic databases

HOGENOMi HOG000281566.
InParanoidi Q89KX1.
KOi K00627.
OrthoDBi EOG610413.
PhylomeDBi Q89KX1.

Enzyme and pathway databases

BioCyci BJAP224911:GJEJ-4812-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110Imported.

Entry informationi

Entry nameiQ89KX1_BRADU
AccessioniPrimary (citable) accession number: Q89KX1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3