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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

bll4779

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • (R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-4812-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:bll4779Imported
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)Imported
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi224911.bll4779.

Structurei

3D structure databases

ProteinModelPortaliQ89KX1.
SMRiQ89KX1. Positions 3-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281566.
InParanoidiQ89KX1.
KOiK00627.
OrthoDBiEOG610413.
PhylomeDBiQ89KX1.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89KX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINILMPAL SPTMEKGNLA KWLKKEGDKV KSGDVIAEIE TDKATMEVEA
60 70 80 90 100
IDEGTIAKIL VPEGTQDVPV NDVIAVLAGE GEDVKAAGAA KPSASAAPPK
110 120 130 140 150
ATDAPAAAPA PATAPAAPKA APPPAAAPAP QAAAPAAQSN GHGGRVFSSP
160 170 180 190 200
LARRLAKDAG IDVSMVTGTG PHGRVVARDV EQAKSGKGLK APAAAPSSAP
210 220 230 240 250
SIAPTMSDKQ ILSLFEPGSY DIVPHDGMRR TIAQRLTASI QNVPHFYLTI
260 270 280 290 300
DCDIGKLLAA REEINAAAPK DKEKKPLYKI SVNDFVIKAM AVALQKIPNC
310 320 330 340 350
NVSWTESGMV KHHHSDVGVA VAMPGGLITP IIRKAETKTL STISNEMKDF
360 370 380 390 400
AARARSRKLK PEEYQGGTTA VSNLGMYGIS HFTAVINPPH ATILAVGTSE
410 420 430 440 450
ERPVVRNGKI EIAHMMSVTL SCDHRAIDGA LGAELIGAFK QLIENPVMMM

V
Length:451
Mass (Da):47,042
Last modified:May 31, 2003 - v1
Checksum:iBFF05B24465E1F85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50044.1.
RefSeqiNP_771419.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC50044; BAC50044; BAC50044.
GeneIDi1052251.
KEGGibja:bll4779.
PATRICi21193212. VBIBraJap65052_4855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50044.1.
RefSeqiNP_771419.1. NC_004463.1.

3D structure databases

ProteinModelPortaliQ89KX1.
SMRiQ89KX1. Positions 3-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.bll4779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC50044; BAC50044; BAC50044.
GeneIDi1052251.
KEGGibja:bll4779.
PATRICi21193212. VBIBraJap65052_4855.

Phylogenomic databases

HOGENOMiHOG000281566.
InParanoidiQ89KX1.
KOiK00627.
OrthoDBiEOG610413.
PhylomeDBiQ89KX1.

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-4812-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110Imported.

Entry informationi

Entry nameiQ89KX1_BRADU
AccessioniPrimary (citable) accession number: Q89KX1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2003
Last sequence update: May 31, 2003
Last modified: January 6, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.