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Q89KV2

- GLSA2_BRADU

UniProt

Q89KV2 - GLSA2_BRADU

Protein

Glutaminase 2

Gene

glsA2

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851SubstrateBy similarity
    Binding sitei134 – 1341SubstrateBy similarity
    Binding sitei178 – 1781SubstrateBy similarity
    Binding sitei185 – 1851SubstrateBy similarity
    Binding sitei209 – 2091SubstrateBy similarity
    Binding sitei261 – 2611SubstrateBy similarity
    Binding sitei279 – 2791Substrate; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi491 – 608118cNMPAdd
    BLAST

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-4831-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminase 2 (EC:3.5.1.2)
    Gene namesi
    Name:glsA2
    Ordered Locus Names:bll4798
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 624624Glutaminase 2PRO_0000110598Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi224911.bll4798.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89KV2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini355 – 466112STASAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni43 – 325283GlutaminaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutaminase family.Curated
    Contains 1 STAS domain.Curated

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OrthoDBiEOG6N94BK.
    PhylomeDBiQ89KV2.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    3.30.750.24. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR015868. Glutaminase.
    IPR014710. RmlC-like_jellyroll.
    IPR002645. STAS_dom.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF00027. cNMP_binding. 1 hit.
    PF04960. Glutaminase. 1 hit.
    PF01740. STAS. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF52091. SSF52091. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89KV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTQPIRLPS VAGATRSAGY PTRPPLRRFL TDCHEEFRGD SSGELADYIP    50
    ELKRANPDHF GIALVTIDGH VYEVGDSAVP FTIQSVSKAF VFALALETVG 100
    EERVSATIGV EPSGEAFNSI RLTNDNRPFN PMVNAGAIAC SGLIYEVDGK 150
    GAFERVRSKL SEFAGRELGV DEAVHASETA TGNRNRAIAW LLRNYAVLPD 200
    DVDAVLDVYF RQCAILVTAR DLAVMAATLA NRGINPVTGA QVITPHIVAR 250
    TLSVMTSSGM YDYAGEWTYR VGIPAKSGVG GGIVAALPSQ LGLGTFSPLL 300
    DNHFNSVRGL KVCEALSARF DLHMLNRNAD VRTSVMADYD VYGISSRRSR 350
    QPHEQQILDE RHSDIRIVEL VGALNFGTID YVTRRLTSEP PNAPLLIIDF 400
    RRVPDITAAG AELLGETLTA LGNANVTTIL SGLEEASAVW AAIAARTGDP 450
    RRLRRFALLD DAIEWAEDQV IYRFGGFTDV KESVHLGEQA LLAELDTDEI 500
    AAIVKLSTTR HYTAGQRVIA AGAPANSLFF LQSGMVSVKL RSGVRLASLG 550
    PGMEFGEMAI LERTRSADVF ADTPVACLEL PLDSFADYRR LHPETALKIM 600
    RNLAAILARR LVAANAKVDL LSAY 624
    Length:624
    Mass (Da):67,583
    Last modified:June 1, 2003 - v1
    Checksum:i75646994C0FF9DAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC50063.1.
    RefSeqiNP_771438.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC50063; BAC50063; BAC50063.
    GeneIDi1052223.
    KEGGibja:bll4798.
    PATRICi21193254. VBIBraJap65052_4876.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC50063.1 .
    RefSeqi NP_771438.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali Q89KV2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.bll4798.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC50063 ; BAC50063 ; BAC50063 .
    GeneIDi 1052223.
    KEGGi bja:bll4798.
    PATRICi 21193254. VBIBraJap65052_4876.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OrthoDBi EOG6N94BK.
    PhylomeDBi Q89KV2.

    Enzyme and pathway databases

    BioCyci BJAP224911:GJEJ-4831-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    3.30.750.24. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR015868. Glutaminase.
    IPR014710. RmlC-like_jellyroll.
    IPR002645. STAS_dom.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF00027. cNMP_binding. 1 hit.
    PF04960. Glutaminase. 1 hit.
    PF01740. STAS. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF52091. SSF52091. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiGLSA2_BRADU
    AccessioniPrimary (citable) accession number: Q89KV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3