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Protein

Glutaminase 2

Gene

glsA2

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851SubstrateBy similarity
Binding sitei134 – 1341SubstrateBy similarity
Binding sitei178 – 1781SubstrateBy similarity
Binding sitei185 – 1851SubstrateBy similarity
Binding sitei209 – 2091SubstrateBy similarity
Binding sitei261 – 2611SubstrateBy similarity
Binding sitei279 – 2791Substrate; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi491 – 608118cNMPAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-4831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 2 (EC:3.5.1.2)
Gene namesi
Name:glsA2
Ordered Locus Names:bll4798
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624Glutaminase 2PRO_0000110598Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi224911.bll4798.

Structurei

3D structure databases

ProteinModelPortaliQ89KV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini355 – 466112STASAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 325283GlutaminaseAdd
BLAST

Sequence similaritiesi

Belongs to the glutaminase family.Curated
Contains 1 STAS domain.Curated

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
InParanoidiQ89KV2.
KOiK01425.
OrthoDBiEOG6N94BK.
PhylomeDBiQ89KV2.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR015868. Glutaminase.
IPR014710. RmlC-like_jellyroll.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF04960. Glutaminase. 1 hit.
PF01740. STAS. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89KV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTQPIRLPS VAGATRSAGY PTRPPLRRFL TDCHEEFRGD SSGELADYIP
60 70 80 90 100
ELKRANPDHF GIALVTIDGH VYEVGDSAVP FTIQSVSKAF VFALALETVG
110 120 130 140 150
EERVSATIGV EPSGEAFNSI RLTNDNRPFN PMVNAGAIAC SGLIYEVDGK
160 170 180 190 200
GAFERVRSKL SEFAGRELGV DEAVHASETA TGNRNRAIAW LLRNYAVLPD
210 220 230 240 250
DVDAVLDVYF RQCAILVTAR DLAVMAATLA NRGINPVTGA QVITPHIVAR
260 270 280 290 300
TLSVMTSSGM YDYAGEWTYR VGIPAKSGVG GGIVAALPSQ LGLGTFSPLL
310 320 330 340 350
DNHFNSVRGL KVCEALSARF DLHMLNRNAD VRTSVMADYD VYGISSRRSR
360 370 380 390 400
QPHEQQILDE RHSDIRIVEL VGALNFGTID YVTRRLTSEP PNAPLLIIDF
410 420 430 440 450
RRVPDITAAG AELLGETLTA LGNANVTTIL SGLEEASAVW AAIAARTGDP
460 470 480 490 500
RRLRRFALLD DAIEWAEDQV IYRFGGFTDV KESVHLGEQA LLAELDTDEI
510 520 530 540 550
AAIVKLSTTR HYTAGQRVIA AGAPANSLFF LQSGMVSVKL RSGVRLASLG
560 570 580 590 600
PGMEFGEMAI LERTRSADVF ADTPVACLEL PLDSFADYRR LHPETALKIM
610 620
RNLAAILARR LVAANAKVDL LSAY
Length:624
Mass (Da):67,583
Last modified:June 1, 2003 - v1
Checksum:i75646994C0FF9DAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50063.1.
RefSeqiNP_771438.1. NC_004463.1.
WP_011087566.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC50063; BAC50063; BAC50063.
GeneIDi1052223.
KEGGibja:bll4798.
PATRICi21193254. VBIBraJap65052_4876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50063.1.
RefSeqiNP_771438.1. NC_004463.1.
WP_011087566.1. NC_004463.1.

3D structure databases

ProteinModelPortaliQ89KV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.bll4798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC50063; BAC50063; BAC50063.
GeneIDi1052223.
KEGGibja:bll4798.
PATRICi21193254. VBIBraJap65052_4876.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
InParanoidiQ89KV2.
KOiK01425.
OrthoDBiEOG6N94BK.
PhylomeDBiQ89KV2.

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-4831-MONOMER.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR015868. Glutaminase.
IPR014710. RmlC-like_jellyroll.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF04960. Glutaminase. 1 hit.
PF01740. STAS. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiGLSA2_BRADU
AccessioniPrimary (citable) accession number: Q89KV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 27, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.