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Q89KQ7 (LPXB_BRADU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:bll4847
OrganismBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) [Reference proteome] [HAMAP]
Taxonomic identifier224911 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190155

Sequences

Sequence LengthMass (Da)Tools
Q89KQ7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7956C1EBD78B9C73

FASTA39243,262
        10         20         30         40         50         60 
MMQGRDPKRK IFLIATEESG DRLGSALMKV LRQRLGDGVQ FEGVGGRTMA REGLETLFPI 

        70         80         90        100        110        120 
EELSIVGFAA VVQQLPKILR LIRETADAVL EAVPDALVII DSPDFTHRVA RRVRARNPAI 

       130        140        150        160        170        180 
PIVDYVSPQL WAWRPGRART MLGYVDHVLG LLPFEPEEYR KLGGPPCSYV GHPLIEQLGS 

       190        200        210        220        230        240 
LRPNAEEQKR RNSELPVLLV LPGSRRSEIR HHIEVFGAAL GRLQAEGRAF ELMLPTMPHL 

       250        260        270        280        290        300 
EATVREGIAS WPVKPQIVIG EAEKRAAFRI AHAALAKSGT VTLELALSGI PMVTAYRVGA 

       310        320        330        340        350        360 
IEAFILRRAI RVSSVILANL VIGEDVIPEF LQEDCTPEKL APALSEVLTD SDMRRRQVEA 

       370        380        390 
FARLDTIMST GNKAPSVLAA DIVLATMRKG RR 

« Hide

References

[1]"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110."
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.
DNA Res. 9:189-197(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000040 Genomic DNA. Translation: BAC50112.1.
RefSeqNP_771487.1. NC_004463.1.

3D structure databases

ProteinModelPortalQ89KQ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224911.bll4847.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC50112; BAC50112; BAC50112.
GeneID1052130.
KEGGbja:bll4847.
PATRIC21193356. VBIBraJap65052_4927.

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OrthoDBEOG6FBWZR.
PhylomeDBQ89KQ7.

Enzyme and pathway databases

BioCycBJAP224911:GJEJ-4880-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_BRADU
AccessionPrimary (citable) accession number: Q89KQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways