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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-4879-MONOMER
UniPathwayiUPA00359; UER00481

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:bll4847
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001901551 – 392Lipid-A-disaccharide synthaseAdd BLAST392

Interactioni

Protein-protein interaction databases

STRINGi224911.bll4847

Structurei

3D structure databases

ProteinModelPortaliQ89KQ7
SMRiQ89KQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018004
InParanoidiQ89KQ7
KOiK00748
OMAiPTVWAWR
OrthoDBiPOG091H01NW
PhylomeDBiQ89KQ7

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

Q89KQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQGRDPKRK IFLIATEESG DRLGSALMKV LRQRLGDGVQ FEGVGGRTMA
60 70 80 90 100
REGLETLFPI EELSIVGFAA VVQQLPKILR LIRETADAVL EAVPDALVII
110 120 130 140 150
DSPDFTHRVA RRVRARNPAI PIVDYVSPQL WAWRPGRART MLGYVDHVLG
160 170 180 190 200
LLPFEPEEYR KLGGPPCSYV GHPLIEQLGS LRPNAEEQKR RNSELPVLLV
210 220 230 240 250
LPGSRRSEIR HHIEVFGAAL GRLQAEGRAF ELMLPTMPHL EATVREGIAS
260 270 280 290 300
WPVKPQIVIG EAEKRAAFRI AHAALAKSGT VTLELALSGI PMVTAYRVGA
310 320 330 340 350
IEAFILRRAI RVSSVILANL VIGEDVIPEF LQEDCTPEKL APALSEVLTD
360 370 380 390
SDMRRRQVEA FARLDTIMST GNKAPSVLAA DIVLATMRKG RR
Length:392
Mass (Da):43,262
Last modified:June 1, 2003 - v1
Checksum:i7956C1EBD78B9C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA Translation: BAC50112.1
RefSeqiNP_771487.1, NC_004463.1
WP_011087615.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC50112; BAC50112; BAC50112
GeneIDi1052130
KEGGibja:bll4847
PATRICifig|224911.5.peg.4927

Similar proteinsi

Entry informationi

Entry nameiLPXB_BRADU
AccessioniPrimary (citable) accession number: Q89KQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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