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Q89KQ7

- LPXB_BRADU

UniProt

Q89KQ7 - LPXB_BRADU

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-4880-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:bll4847
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Lipid-A-disaccharide synthasePRO_0000190155Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224911.bll4847.

Structurei

3D structure databases

ProteinModelPortaliQ89KQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
InParanoidiQ89KQ7.
KOiK00748.
OrthoDBiEOG6FBWZR.
PhylomeDBiQ89KQ7.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89KQ7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMQGRDPKRK IFLIATEESG DRLGSALMKV LRQRLGDGVQ FEGVGGRTMA
60 70 80 90 100
REGLETLFPI EELSIVGFAA VVQQLPKILR LIRETADAVL EAVPDALVII
110 120 130 140 150
DSPDFTHRVA RRVRARNPAI PIVDYVSPQL WAWRPGRART MLGYVDHVLG
160 170 180 190 200
LLPFEPEEYR KLGGPPCSYV GHPLIEQLGS LRPNAEEQKR RNSELPVLLV
210 220 230 240 250
LPGSRRSEIR HHIEVFGAAL GRLQAEGRAF ELMLPTMPHL EATVREGIAS
260 270 280 290 300
WPVKPQIVIG EAEKRAAFRI AHAALAKSGT VTLELALSGI PMVTAYRVGA
310 320 330 340 350
IEAFILRRAI RVSSVILANL VIGEDVIPEF LQEDCTPEKL APALSEVLTD
360 370 380 390
SDMRRRQVEA FARLDTIMST GNKAPSVLAA DIVLATMRKG RR
Length:392
Mass (Da):43,262
Last modified:June 1, 2003 - v1
Checksum:i7956C1EBD78B9C73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC50112.1.
RefSeqiNP_771487.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC50112; BAC50112; BAC50112.
GeneIDi1052130.
KEGGibja:bll4847.
PATRICi21193356. VBIBraJap65052_4927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC50112.1 .
RefSeqi NP_771487.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q89KQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.bll4847.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC50112 ; BAC50112 ; BAC50112 .
GeneIDi 1052130.
KEGGi bja:bll4847.
PATRICi 21193356. VBIBraJap65052_4927.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
InParanoidi Q89KQ7.
KOi K00748.
OrthoDBi EOG6FBWZR.
PhylomeDBi Q89KQ7.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BJAP224911:GJEJ-4880-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiLPXB_BRADU
AccessioniPrimary (citable) accession number: Q89KQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3