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Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit DUniRule annotation
NDH-1 subunit DUniRule annotation
Gene namesi
Name:nuoDUniRule annotation
Ordered Locus Names:bll4916
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003577791 – 398NADH-quinone oxidoreductase subunit DAdd BLAST398

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi224911.bll4916.

Structurei

3D structure databases

ProteinModelPortaliQ89KI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQV. Bacteria.
COG0649. LUCA.
HOGENOMiHOG000228264.
InParanoidiQ89KI9.
KOiK00333.
OMAiMADVITI.
OrthoDBiPOG091H08K1.
PhylomeDBiQ89KI9.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD. 1 hit.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89KI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEQPENLRN FTINFGPQHP AAHGVLRLVL ELDGEIVARV DPHIGLLHRG
60 70 80 90 100
TEKLIEQKTY LQAIPYFDRL DYVAPMNQEH AFCLAAEKLL GIEVPRRGQL
110 120 130 140 150
IRVLYCEIGR ILSHLLNVTT QAMDVGALTP PLWGFEEREK LMVFYERASG
160 170 180 190 200
SRMHAAFFRV GGVHQDLPQK LVDDIEAWCD PFLKVVDDLD RLLTANRIFK
210 220 230 240 250
QRNVDIGVVP LKEAWEWGFS GVMVRGSGAA WDLRKSQPYE CYAEMDFDIP
260 270 280 290 300
IGKNGDCYDR YLIRMEEMRQ SVRIMRQCIQ KLNAPEGKGP VVVEDNKVAP
310 320 330 340 350
PRRGEMKRSM EALIHHFKLY TEGVHVPAGE VYAAVEAPKG EFGVYLVADG
360 370 380 390
TNKPYKCKIR APGFAHLQAM DHICRGHLLA DVSAILGSLD IVFGEVDR
Length:398
Mass (Da):45,058
Last modified:June 1, 2003 - v1
Checksum:i9EF9233422304D86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50181.1.
RefSeqiNP_771556.1. NC_004463.1.
WP_011087682.1. NZ_CP011360.1.

Genome annotation databases

EnsemblBacteriaiBAC50181; BAC50181; BAC50181.
GeneIDi1052040.
KEGGibja:bll4916.
PATRICi21193504. VBIBraJap65052_5001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50181.1.
RefSeqiNP_771556.1. NC_004463.1.
WP_011087682.1. NZ_CP011360.1.

3D structure databases

ProteinModelPortaliQ89KI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.bll4916.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC50181; BAC50181; BAC50181.
GeneIDi1052040.
KEGGibja:bll4916.
PATRICi21193504. VBIBraJap65052_5001.

Phylogenomic databases

eggNOGiENOG4105CQV. Bacteria.
COG0649. LUCA.
HOGENOMiHOG000228264.
InParanoidiQ89KI9.
KOiK00333.
OMAiMADVITI.
OrthoDBiPOG091H08K1.
PhylomeDBiQ89KI9.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD. 1 hit.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUOD_BRADU
AccessioniPrimary (citable) accession number: Q89KI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.