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Protein

Pantothenate synthetase 2

Gene

panC2

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathway:i(R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase 2 (panC2), Pantothenate synthetase 1 (panC1)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton donorUniRule annotation
Binding sitei65 – 651Beta-alanineUniRule annotation
Binding sitei65 – 651PantoateUniRule annotation
Binding sitei158 – 1581PantoateUniRule annotation
Binding sitei181 – 1811ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418ATPUniRule annotation
Nucleotide bindingi152 – 1554ATPUniRule annotation
Nucleotide bindingi189 – 1924ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-5200-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase 2UniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PS 2UniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligase 2UniRule annotation
Pantoate-activating enzyme 2UniRule annotation
Gene namesi
Name:panC2UniRule annotation
Ordered Locus Names:blr5162
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pantothenate synthetase 2PRO_0000305409Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224911.blr5162.

Structurei

3D structure databases

ProteinModelPortaliQ89JV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiQ89JV7.
KOiK01918.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ89JV7.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89JV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSPLIART VPALRRAADN LRKRKATIAL VPTMGALHDG HVSLVRLAKR
60 70 80 90 100
RASRVVVSIF VNPTQFAPTE DFGAYPRTWK ADIAKLAAED VDIVWHPGVE
110 120 130 140 150
AMYPEGFATR IVPEGPALAG LEDRFRPHFF GGVATVVGKL FTQCRPDFAI
160 170 180 190 200
FGEKDFQQLR VVTQMARDLD LGVKVIGSRT VRERDGLAMS SRNVYLSPQE
210 220 230 240 250
RQTATTLYRA MKDSAGRIRA GEAIASAMAR GAATIKAAGF VLDYFEARHA
260 270 280
ETLAQVTSRK DGPLRILVAA KLGTTRLIDN IAV
Length:283
Mass (Da):30,969
Last modified:June 1, 2003 - v1
Checksum:i3EFFFB820731629C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50427.1.
RefSeqiNP_771802.1. NC_004463.1.
WP_011087920.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC50427; BAC50427; BAC50427.
GeneIDi1051570.
KEGGibja:blr5162.
PATRICi21194004. VBIBraJap65052_5246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50427.1.
RefSeqiNP_771802.1. NC_004463.1.
WP_011087920.1. NC_004463.1.

3D structure databases

ProteinModelPortaliQ89JV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.blr5162.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC50427; BAC50427; BAC50427.
GeneIDi1051570.
KEGGibja:blr5162.
PATRICi21194004. VBIBraJap65052_5246.

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiQ89JV7.
KOiK01918.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ89JV7.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.
BioCyciBJAP224911:GJEJ-5200-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiPANC2_BRADU
AccessioniPrimary (citable) accession number: Q89JV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2003
Last modified: May 27, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.