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Q89JV7

- PANC2_BRADU

UniProt

Q89JV7 - PANC2_BRADU

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Protein
Pantothenate synthetase 2
Gene
panC2, blr5162
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton donor By similarity
Binding sitei65 – 651Beta-alanine By similarity
Binding sitei65 – 651Pantoate By similarity
Binding sitei158 – 1581Pantoate By similarity
Binding sitei181 – 1811ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418ATP By similarity
Nucleotide bindingi152 – 1554ATP By similarity
Nucleotide bindingi189 – 1924ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-5200-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase 2 (EC:6.3.2.1)
Short name:
PS 2
Alternative name(s):
Pantoate--beta-alanine ligase 2
Pantoate-activating enzyme 2
Gene namesi
Name:panC2
Ordered Locus Names:blr5162
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pantothenate synthetase 2UniRule annotation
PRO_0000305409Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224911.blr5162.

Structurei

3D structure databases

ProteinModelPortaliQ89JV7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OrthoDBiEOG6Z6FZ4.
PhylomeDBiQ89JV7.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89JV7-1 [UniParc]FASTAAdd to Basket

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MSRSPLIART VPALRRAADN LRKRKATIAL VPTMGALHDG HVSLVRLAKR    50
RASRVVVSIF VNPTQFAPTE DFGAYPRTWK ADIAKLAAED VDIVWHPGVE 100
AMYPEGFATR IVPEGPALAG LEDRFRPHFF GGVATVVGKL FTQCRPDFAI 150
FGEKDFQQLR VVTQMARDLD LGVKVIGSRT VRERDGLAMS SRNVYLSPQE 200
RQTATTLYRA MKDSAGRIRA GEAIASAMAR GAATIKAAGF VLDYFEARHA 250
ETLAQVTSRK DGPLRILVAA KLGTTRLIDN IAV 283
Length:283
Mass (Da):30,969
Last modified:June 1, 2003 - v1
Checksum:i3EFFFB820731629C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC50427.1.
RefSeqiNP_771802.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC50427; BAC50427; BAC50427.
GeneIDi1051570.
KEGGibja:blr5162.
PATRICi21194004. VBIBraJap65052_5246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC50427.1 .
RefSeqi NP_771802.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q89JV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.blr5162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC50427 ; BAC50427 ; BAC50427 .
GeneIDi 1051570.
KEGGi bja:blr5162.
PATRICi 21194004. VBIBraJap65052_5246.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OrthoDBi EOG6Z6FZ4.
PhylomeDBi Q89JV7.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci BJAP224911:GJEJ-5200-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiPANC2_BRADU
AccessioniPrimary (citable) accession number: Q89JV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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