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Q89JV7

- PANC2_BRADU

UniProt

Q89JV7 - PANC2_BRADU

Protein

Pantothenate synthetase 2

Gene

panC2

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411Proton donorUniRule annotation
    Binding sitei65 – 651Beta-alanineUniRule annotation
    Binding sitei65 – 651PantoateUniRule annotation
    Binding sitei158 – 1581PantoateUniRule annotation
    Binding sitei181 – 1811ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 418ATPUniRule annotation
    Nucleotide bindingi152 – 1554ATPUniRule annotation
    Nucleotide bindingi189 – 1924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-5200-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetase 2UniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PS 2UniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligase 2UniRule annotation
    Pantoate-activating enzyme 2UniRule annotation
    Gene namesi
    Name:panC2UniRule annotation
    Ordered Locus Names:blr5162
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Pantothenate synthetase 2PRO_0000305409Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224911.blr5162.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89JV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OrthoDBiEOG6Z6FZ4.
    PhylomeDBiQ89JV7.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q89JV7-1 [UniParc]FASTAAdd to Basket

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    MSRSPLIART VPALRRAADN LRKRKATIAL VPTMGALHDG HVSLVRLAKR    50
    RASRVVVSIF VNPTQFAPTE DFGAYPRTWK ADIAKLAAED VDIVWHPGVE 100
    AMYPEGFATR IVPEGPALAG LEDRFRPHFF GGVATVVGKL FTQCRPDFAI 150
    FGEKDFQQLR VVTQMARDLD LGVKVIGSRT VRERDGLAMS SRNVYLSPQE 200
    RQTATTLYRA MKDSAGRIRA GEAIASAMAR GAATIKAAGF VLDYFEARHA 250
    ETLAQVTSRK DGPLRILVAA KLGTTRLIDN IAV 283
    Length:283
    Mass (Da):30,969
    Last modified:June 1, 2003 - v1
    Checksum:i3EFFFB820731629C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC50427.1.
    RefSeqiNP_771802.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC50427; BAC50427; BAC50427.
    GeneIDi1051570.
    KEGGibja:blr5162.
    PATRICi21194004. VBIBraJap65052_5246.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000040 Genomic DNA. Translation: BAC50427.1 .
    RefSeqi NP_771802.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali Q89JV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.blr5162.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC50427 ; BAC50427 ; BAC50427 .
    GeneIDi 1051570.
    KEGGi bja:blr5162.
    PATRICi 21194004. VBIBraJap65052_5246.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OrthoDBi EOG6Z6FZ4.
    PhylomeDBi Q89JV7.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci BJAP224911:GJEJ-5200-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiPANC2_BRADU
    AccessioniPrimary (citable) accession number: Q89JV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3