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Q89IW2

- GCH1_BRADU

UniProt

Q89IW2 - GCH1_BRADU

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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi118 – 1181ZincUniRule annotation
Metal bindingi121 – 1211ZincUniRule annotation
Metal bindingi189 – 1891ZincUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-5566-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:bll5522
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229GTP cyclohydrolase 1PRO_0000119389Add
BLAST

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi224911.bll5522.

Structurei

3D structure databases

ProteinModelPortaliQ89IW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
InParanoidiQ89IW2.
KOiK01495.
OrthoDBiEOG6XHC8G.
PhylomeDBiQ89IW2.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89IW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDATIKSIRP SKPSDRQPES RPAELDPAEF LAAAVRADQP RPARAQAEAA
60 70 80 90 100
VKTLLAYIGE NTEREGLLDT PRRVVEAFDE LYQGYHQCPA EVLDRTFGET
110 120 130 140 150
AGYDDFVLVR DIEFTSQCEH HMMPFYGKAH IAYTPVERVV GLSKLARLTD
160 170 180 190 200
IFARRLQTQE HLTAQIAAAI DEVLKPRGVA VLIEAEHTCM SVRGVAKHGA
210 220
STFTSRFTGM FRDNPAEQAR FLSLVRGTR
Length:229
Mass (Da):25,543
Last modified:June 1, 2003 - v1
Checksum:i0D27E16783188A51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50787.1.
RefSeqiNP_772162.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC50787; BAC50787; BAC50787.
GeneIDi1051113.
KEGGibja:bll5522.
PATRICi21194774. VBIBraJap65052_5625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000040 Genomic DNA. Translation: BAC50787.1 .
RefSeqi NP_772162.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q89IW2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.bll5522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC50787 ; BAC50787 ; BAC50787 .
GeneIDi 1051113.
KEGGi bja:bll5522.
PATRICi 21194774. VBIBraJap65052_5625.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
InParanoidi Q89IW2.
KOi K01495.
OrthoDBi EOG6XHC8G.
PhylomeDBi Q89IW2.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BJAP224911:GJEJ-5566-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiGCH1_BRADU
AccessioniPrimary (citable) accession number: Q89IW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3