Reviewed, UniProtKB/Swiss-Prot Q89IB0 (PUR71_BRAJA)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase A
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase A

Gene names

Name:	purC1
Ordered Locus Names:	bll5729

Organism

Bradyrhizobium japonicum [Complete proteome] [HAMAP]

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Phosphoribosylaminoimidazole-succinocarboxamide synthase A HAMAP MF_00137		PRO_0000100807

Sequences

	Sequence		Length	Mass (Da)
	Q89IB0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 961AB39593EEBF19	FASTA	255	29,186
	10 20 30 40 50 60 MSRRRRIYEG KAKVLYEGPE PGTLIQHFKD DATAFNAKKH QVIEGKGVLN NRISEYLFQH 70 80 90 100 110 120 LNDIGVPTHF IRRLNMREQL IREVEIVPLE VVVRNVAAGS LSQRLGIEEG TQLPRSIIEF 130 140 150 160 170 180 YYKNDQLNDP MVSEEHITAF GWATPQEIDD IMALAIRVND FLTGLFLGIG IRLVDFKMEC 190 200 210 220 230 240 GRLFENEMMR IIVADEISPD SCRLWDIKSN EKLDKDRFRR DLGGLLEAYT EVAKRLGILM 250 ENERPAGSGP VLVKS

References

[1]

"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000040 Genomic DNA. Translation: BAC50994.1.
RefSeq	NP_772369.1.
3D structure databases
HSSP	HSSP built from PDB template 1KUT based on UniProtKB Q9X0X0.
ModBase	Search...
Genome annotation databases
GeneID	1048812.
GenomeReviews	Gene locus bll5729 in contig BA000040_GR.
KEGG	bja:bll5729.
NMPDR	fig|224911.1.peg.5729.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89IB0.
OMA	Q89IB0. TAFNAQK.
Enzyme and pathway databases
BioCyc	BJAP224911:BLL5729-MON.
BRENDA	6.3.2.6. 280.
Family and domain databases
HAMAP	MF_00137. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
ProDom	PD003043. SAICAR_synt. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR71_BRAJA

Accession

Primary (citable) accession number: Q89IB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)