Reviewed, UniProtKB/Swiss-Prot Q89GX0 (HIS81_BRAJA)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	blr6225

Organism

Bradyrhizobium japonicum [Complete proteome] [HAMAP]

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153325
Amino acid modifications
	Modified residue	209	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q89GX0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F51B67F2BE9D7805	FASTA	350	38,774
	10 20 30 40 50 60 MSRFWSPVVR TLSPYVPGEQ PKQDGVVKLN TNENPYPPSP RVLAAIASAA ERLRLYPDPR 70 80 90 100 110 120 ATRLREAIAA YCDVAAEQVF VGNGSDEVLA HTFPALLKHD RPLLFPDVTY SFYPVYCRLY 130 140 150 160 170 180 GVAHEEVPLD AAMRIEIADY RRPSSAILLC NPNAPTGIAL PRDAVAALLA ENPDRLVVVD 190 200 210 220 230 240 EAYVDFGAES AVPLVAHHDN LLVIQTFSKS RALAGLRVGF AIGQRPLIEA LERVKDSFNS 250 260 270 280 290 300 YPVDCLAIAG AVAAIEDEAW FLESRTRIIA SRDVLTRDLA QLGFEVLPSL ANFVFARHRR 310 320 330 340 350 RSGADLAAAL RQRGVLVRHF KKPRIEDFLR ITVGTDEQCG RLIEVLRELI

References

[1]

"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000040 Genomic DNA. Translation: BAC51490.1.
RefSeq	NP_772865.1.
3D structure databases
SMR	Q89GX0. Positions 19-348.
ModBase	Search...
Genome annotation databases
GeneID	1053013.
GenomeReviews	Gene locus blr6225 in contig BA000040_GR.
KEGG	bja:blr6225.
NMPDR	fig|224911.1.peg.6225.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646350.
OMA	LAHIFHG.
PhylomeDB	Q89GX0.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR6225-MONOMER.
BRENDA	2.6.1.9. 280.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_BRAJA

Accession

Primary (citable) accession number: Q89GX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)