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Q89FY1

- ASPD_BRADU

UniProt

Q89FY1 - ASPD_BRADU

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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341NAD; via amide nitrogenUniRule annotation
Binding sitei202 – 2021NADUniRule annotation
Active sitei232 – 2321UniRule annotation

GO - Molecular functioni

  1. aspartate dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADP binding Source: UniProtKB-HAMAP
  4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-6617-MONOMER.
UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:bll6567
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Probable L-aspartate dehydrogenasePRO_0000144887Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224911.bll6567.

Structurei

3D structure databases

ProteinModelPortaliQ89FY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000206326.
InParanoidiQ89FY1.
KOiK06989.
OrthoDBiEOG6VTK2D.
PhylomeDBiQ89FY1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01265. NadX.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89FY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRRWKVMTD QTASSELRVA IAGLGSIGTK IAAALDQGEG LTLSAVAVRD
60 70 80 90 100
PAKHQAFLNG LRRPPQVLPI DQLGEAADIV VECAPSSQLR AIVEPAVKRG
110 120 130 140 150
KAAVVVSVGG LLDNFDLVDL ARANGGRIIV PTGALIGLDA VNAAVIGTIH
160 170 180 190 200
SVKMVTRKPI DGLKGAPFIV HNNIDIDTLR EPLKLFEGTA REAAKGFPAN
210 220 230 240 250
LNVAVALSLA GVGPDRTSVQ IWADPTVTRN VHRIEVEADS ARFSMSIENI
260 270 280
PSENPKTGLI TALSVIALLR KQRATLCVGT
Length:280
Mass (Da):29,472
Last modified:June 1, 2003 - v1
Checksum:i545EC9E5ACBB4F75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC51832.1.
RefSeqiNP_773207.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC51832; BAC51832; BAC51832.
GeneIDi1050893.
KEGGibja:bll6567.
PATRICi21196980. VBIBraJap65052_6724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000040 Genomic DNA. Translation: BAC51832.1 .
RefSeqi NP_773207.1. NC_004463.1.

3D structure databases

ProteinModelPortali Q89FY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.bll6567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC51832 ; BAC51832 ; BAC51832 .
GeneIDi 1050893.
KEGGi bja:bll6567.
PATRICi 21196980. VBIBraJap65052_6724.

Phylogenomic databases

eggNOGi COG1712.
HOGENOMi HOG000206326.
InParanoidi Q89FY1.
KOi K06989.
OrthoDBi EOG6VTK2D.
PhylomeDBi Q89FY1.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00456 .
BioCyci BJAP224911:GJEJ-6617-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01265. NadX.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiASPD_BRADU
AccessioniPrimary (citable) accession number: Q89FY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3