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Q89FU8 (MURC_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:bll6601
OrganismBradyrhizobium japonicum
Taxonomic identifier375 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm By similarity HAMAP MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_0000182065

Regions

Nucleotide binding114 – 1207ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q89FU8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 93CB99B69AECA407

FASTA46749,934
        10         20         30         40         50         60 
MRLPREIGPI HFVGIGGIGM SGIAEVLVNL GYAVQGSDAS DNYNLDRLRK KGAKVSVGHK 

        70         80         90        100        110        120 
AENVDGAEVV VVSTAIKRDN PELMAARERR IPVVRRAEML AELMRLKSCV AIAGTHGKTT 

       130        140        150        160        170        180 
TTTMVATLLD AGGLDPTVIN GGIINAYGSN ARLGAGDWMV VEADESDGTF LKLPTDVAIV 

       190        200        210        220        230        240 
TNVDPEHLDH FKTFEAVQDA FRHFVENLPF YGFAVMCIDH PVVQSLVGKI EDRRIITYGE 

       250        260        270        280        290        300 
NPQADVRLVD LTPMGGGSKF KVAFRDRKTG AVHEIPDLML PMPGRHNASN ATAAIAVARE 

       310        320        330        340        350        360 
LGVSDEAIRS AIAGFGGVKR RFTKTGEWNG VTVIDDYGHH PVEIAAVLKA ARESTNGKIV 

       370        380        390        400        410        420 
AVVQPHRYTR LQSLFEEFCT CFNDADAVIV ADVYAAGEAP IDGIDRDHFV AGLRAHGHRE 

       430        440        450        460 
VVPLPAAPEL AGIVKGLAKS GDLVVCLGAG NITQWAYALP GELNALG

« Hide

References

[1]"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110."
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.
DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USDA 110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000040 Genomic DNA. Translation: BAC51866.1.
RefSeqNP_773241.1. NC_004463.1.

3D structure databases

ProteinModelPortalQ89FU8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1052468.
GenomeReviewsGene locus bll6601 in contig BA000040_GR.
KEGGbja:bll6601.
NMPDRfig|224911.1.peg.6601.
PATRIC21197052. VBIBraJap65052_6760.

Phylogenomic databases

HOGENOMHBG476594.
OMAYQPHRYS.
PhylomeDBQ89FU8.
ProtClustDBPRK00421.

Enzyme and pathway databases

BioCycBJAP224911:BLL6601-MONOMER.

Family and domain databases

HAMAPMF_00046. MurC.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01924.
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. MurC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_BRAJA
AccessionPrimary (citable) accession number: Q89FU8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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