Reviewed, UniProtKB/Swiss-Prot Q89AY4 (FABB_BUCBP)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 1
    EC=2.3.1.41
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase I
    Beta-ketoacyl-ACP synthase I
      Short name=KAS I

Gene names

Name:	fabB
Ordered Locus Names:	bbp_086

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.
Catalytic activity	Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the beta-ketoacyl-ACP synthases family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	3-oxoacyl-[acyl-carrier-protein] synthase 1		PRO_0000180310
Sites
	Active site	164	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q89AY4-1 [UniParc]. Last modified May 30, 2003. Version 1. Checksum: F2A07A7744977193	FASTA	407	44,482
	10 20 30 40 50 60 MKRVVITGLG IISSIGNNKI EVLTSLLETK SGISFSKEME RSGMRSHVWG NIKLDNYQEN 70 80 90 100 110 120 IDRKIFRFMN DASIYSYLSM KQAIEDAKLT SKMYQNNPRV GVIIGSSSGS PRCQINGVSI 130 140 150 160 170 180 IKKTKRLKSV SPYTVIKSMT SSISACLSTL FKIQGVNYSI SSACATSAHC IGNAMELIQL 190 200 210 220 230 240 GKQDLIFAGG GEELSWELAC AFDSMGALST MYNSQPILSS RVFDYYRDGF VISGGAGILV 250 260 270 280 290 300 VEELNYALSR SAHIYAEIVG YGTSSDGYNV VVPSGNGAMR CMNIAMSNIQ EPIDYLNVHS 310 320 330 340 350 360 TSTKIGDLIE LNAIQQVFRK TSIPILSSTK SITGHSLGAS GVQEMIYSLL MLKYNFIVPS 370 380 390 400 INIFKLDPKA KNCNILTTMM RKELSIIMSN SFGFGGTNVS LIIKKFV

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO26821.1.
RefSeq	NP_777716.1.
3D structure databases
SMR	Q89AY4. Positions 1-406.
ModBase	Search...
Genome annotation databases
GeneID	1058210.
GenomeReviews	Gene locus bbp_086 in contig AE016826_GR.
KEGG	bab:bbp086.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG757733.
OMA	RSAHIYA.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_086-MONOMER.
Family and domain databases
InterPro	IPR000794. Beta-ketoacyl_synthase. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. [Graphical view]
PROSITE	PS00606. B_KETOACYL_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABB_BUCBP

Accession

Primary (citable) accession number: Q89AY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	May 30, 2003
Last modified:	January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)