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Q89AY4 (FABB_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1
EC=2.3.1.41
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase I
Beta-ketoacyl-ACP synthase I
Short name=KAS I
Gene names
Name:fabB
Ordered Locus Names:bbp_086
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Lipid synthesis
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-oxoacyl-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4074073-oxoacyl-[acyl-carrier-protein] synthase 1
PRO_0000180310

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q89AY4 [UniParc].

Last modified May 30, 2003. Version 1.
Checksum: F2A07A7744977193

FASTA40744,482
        10         20         30         40         50         60 
MKRVVITGLG IISSIGNNKI EVLTSLLETK SGISFSKEME RSGMRSHVWG NIKLDNYQEN 

        70         80         90        100        110        120 
IDRKIFRFMN DASIYSYLSM KQAIEDAKLT SKMYQNNPRV GVIIGSSSGS PRCQINGVSI 

       130        140        150        160        170        180 
IKKTKRLKSV SPYTVIKSMT SSISACLSTL FKIQGVNYSI SSACATSAHC IGNAMELIQL 

       190        200        210        220        230        240 
GKQDLIFAGG GEELSWELAC AFDSMGALST MYNSQPILSS RVFDYYRDGF VISGGAGILV 

       250        260        270        280        290        300 
VEELNYALSR SAHIYAEIVG YGTSSDGYNV VVPSGNGAMR CMNIAMSNIQ EPIDYLNVHS 

       310        320        330        340        350        360 
TSTKIGDLIE LNAIQQVFRK TSIPILSSTK SITGHSLGAS GVQEMIYSLL MLKYNFIVPS 

       370        380        390        400 
INIFKLDPKA KNCNILTTMM RKELSIIMSN SFGFGGTNVS LIIKKFV

« Hide

References

[1]"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016826 Genomic DNA. Translation: AAO26821.1.
RefSeqNP_777716.1. NC_004545.1.

3D structure databases

ProteinModelPortalQ89AY4.
SMRQ89AY4. Positions 1-406.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002287; EBBUCP00000002111; EBBUCG00000002287.
GeneID1058210.
GenomeReviewsGene locus bbp_086 in contig AE016826_GR.
KEGGbab:bbp086.
PATRIC21244951. VBIBucAph80364_0083.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007996.
HOGENOMHBG757733.
OMARSAHIYA.

Enzyme and pathway databases

BioCycBAPH224915:BBP_086-MONOMER.

Family and domain databases

InterProIPR000794. Beta-ketoacyl_synthase.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00647.
PANTHERPTHR11712. Ketoacyl_synth. 1 hit.
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 2 hits.
PROSITEPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABB_BUCBP
AccessionPrimary (citable) accession number: Q89AY4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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