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Q89AY4

- FABB_BUCBP

UniProt

Q89AY4 - FABB_BUCBP

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 1

Gene

fabB

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity).By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-86-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.41)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase I
Beta-ketoacyl-ACP synthase I
Short name:
KAS I
Gene namesi
Name:fabB
Ordered Locus Names:bbp_086
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4074073-oxoacyl-[acyl-carrier-protein] synthase 1PRO_0000180310Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224915.bbp086.

Structurei

3D structure databases

ProteinModelPortaliQ89AY4.
SMRiQ89AY4. Positions 1-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiCOG0304.
KOiK00647.
OMAiNYLAMEQ.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89AY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRVVITGLG IISSIGNNKI EVLTSLLETK SGISFSKEME RSGMRSHVWG
60 70 80 90 100
NIKLDNYQEN IDRKIFRFMN DASIYSYLSM KQAIEDAKLT SKMYQNNPRV
110 120 130 140 150
GVIIGSSSGS PRCQINGVSI IKKTKRLKSV SPYTVIKSMT SSISACLSTL
160 170 180 190 200
FKIQGVNYSI SSACATSAHC IGNAMELIQL GKQDLIFAGG GEELSWELAC
210 220 230 240 250
AFDSMGALST MYNSQPILSS RVFDYYRDGF VISGGAGILV VEELNYALSR
260 270 280 290 300
SAHIYAEIVG YGTSSDGYNV VVPSGNGAMR CMNIAMSNIQ EPIDYLNVHS
310 320 330 340 350
TSTKIGDLIE LNAIQQVFRK TSIPILSSTK SITGHSLGAS GVQEMIYSLL
360 370 380 390 400
MLKYNFIVPS INIFKLDPKA KNCNILTTMM RKELSIIMSN SFGFGGTNVS

LIIKKFV
Length:407
Mass (Da):44,482
Last modified:May 30, 2003 - v1
Checksum:iF2A07A7744977193
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO26821.1.
RefSeqiNP_777716.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26821; AAO26821; bbp_086.
GeneIDi1058210.
KEGGibab:bbp086.
PATRICi21244951. VBIBucAph80364_0083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO26821.1 .
RefSeqi NP_777716.1. NC_004545.1.

3D structure databases

ProteinModelPortali Q89AY4.
SMRi Q89AY4. Positions 1-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO26821 ; AAO26821 ; bbp_086 .
GeneIDi 1058210.
KEGGi bab:bbp086.
PATRICi 21244951. VBIBucAph80364_0083.

Phylogenomic databases

eggNOGi COG0304.
KOi K00647.
OMAi NYLAMEQ.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci BAPH224915:GJ9D-86-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiFABB_BUCBP
AccessioniPrimary (citable) accession number: Q89AY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3