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Q89AY4

- FABB_BUCBP

UniProt

Q89AY4 - FABB_BUCBP

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 1

Gene

fabB

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (30 May 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-86-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.41)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase I
    Beta-ketoacyl-ACP synthase I
    Short name:
    KAS I
    Gene namesi
    Name:fabB
    Ordered Locus Names:bbp_086
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4074073-oxoacyl-[acyl-carrier-protein] synthase 1PRO_0000180310Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi224915.bbp086.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89AY4.
    SMRiQ89AY4. Positions 1-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    KOiK00647.
    OMAiNYLAMEQ.
    OrthoDBiEOG6DG2SR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89AY4-1 [UniParc]FASTAAdd to Basket

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    MKRVVITGLG IISSIGNNKI EVLTSLLETK SGISFSKEME RSGMRSHVWG    50
    NIKLDNYQEN IDRKIFRFMN DASIYSYLSM KQAIEDAKLT SKMYQNNPRV 100
    GVIIGSSSGS PRCQINGVSI IKKTKRLKSV SPYTVIKSMT SSISACLSTL 150
    FKIQGVNYSI SSACATSAHC IGNAMELIQL GKQDLIFAGG GEELSWELAC 200
    AFDSMGALST MYNSQPILSS RVFDYYRDGF VISGGAGILV VEELNYALSR 250
    SAHIYAEIVG YGTSSDGYNV VVPSGNGAMR CMNIAMSNIQ EPIDYLNVHS 300
    TSTKIGDLIE LNAIQQVFRK TSIPILSSTK SITGHSLGAS GVQEMIYSLL 350
    MLKYNFIVPS INIFKLDPKA KNCNILTTMM RKELSIIMSN SFGFGGTNVS 400
    LIIKKFV 407
    Length:407
    Mass (Da):44,482
    Last modified:May 30, 2003 - v1
    Checksum:iF2A07A7744977193
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO26821.1.
    RefSeqiNP_777716.1. NC_004545.1.
    WP_011091222.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO26821; AAO26821; bbp_086.
    GeneIDi1058210.
    KEGGibab:bbp086.
    PATRICi21244951. VBIBucAph80364_0083.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO26821.1 .
    RefSeqi NP_777716.1. NC_004545.1.
    WP_011091222.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali Q89AY4.
    SMRi Q89AY4. Positions 1-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp086.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO26821 ; AAO26821 ; bbp_086 .
    GeneIDi 1058210.
    KEGGi bab:bbp086.
    PATRICi 21244951. VBIBucAph80364_0083.

    Phylogenomic databases

    eggNOGi COG0304.
    KOi K00647.
    OMAi NYLAMEQ.
    OrthoDBi EOG6DG2SR.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci BAPH224915:GJ9D-86-MONOMER.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiFABB_BUCBP
    AccessioniPrimary (citable) accession number: Q89AY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2003
    Last sequence update: May 30, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3