Reviewed, UniProtKB/Swiss-Prot Q89AX5 (6PGD_BUCBP)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:	gnd
Ordered Locus Names:	bbp_101

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090030

Sequences

	Sequence		Length	Mass (Da)
	Q89AX5-1 [UniParc]. Last modified May 30, 2003. Version 1. Checksum: C28B8C09CCB64E11	FASTA	468	52,646
	10 20 30 40 50 60 MAKQQIGVIG MAVMGRNLAL NMERNQYTVS IFNRSLDITE KIILNNPNKN LFPFFSIKDF 70 80 90 100 110 120 VLSLIVPRCI VLMIKSGVAT DDTIKSLIPY LSKGDIIIDG GNTFYKDTIQ RGYELLKIGV 130 140 150 160 170 180 NLIGAGFSGG EKGALYGPSI MPGGRQEAYN YVSPILKKIA SNSEGIPCVT YIGPDGSGHY 190 200 210 220 230 240 VKMVHNGIEY GDMQLIAESY FILKTLLRLD NQSISKIFDI WNQGELNSYL IDITKDILIK 250 260 270 280 290 300 KDDQNNYLID CILDEGSSKG TGTWTTKSAL DLNEPLTLIT ESVFFRYLSS LKSQRLLASK 310 320 330 340 350 360 ILCGPKDFFI VLNRDDFIEK IRQALYLGKI ISYAQGFSQL NSASQKYNWN LKLGEISRIF 370 380 390 400 410 420 QSGCIIRAKL LKNITQEYSS NNNFVNLLLT PYFREIANTY HSSLREIVSI SVKYGIPIPA 430 440 450 460 LSSAISYFDS YRSAFLPSNL IQAQRDFFGA HTYKRIDKSG IFHTNWYS

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO26836.1.
RefSeq	NP_777731.1.
3D structure databases
SMR	Q89AX5. Positions 1-468.
ModBase	Search...
Genome annotation databases
GeneID	1058155.
GenomeReviews	Gene locus bbp_101 in contig AE016826_GR.
KEGG	bab:bbp101.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG286913.
OMA	GQKEAYD.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_101-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_BUCBP

Accession

Primary (citable) accession number: Q89AX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	May 30, 2003
Last modified:	February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)