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Q89AX5

- 6PGD_BUCBP

UniProt

Q89AX5 - 6PGD_BUCBP

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
gnd, bbp_101
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021NADP By similarity
Binding sitei102 – 1021Substrate By similarity
Active sitei182 – 1821Proton acceptor By similarity
Active sitei189 – 1891Proton donor By similarity
Binding sitei190 – 1901Substrate By similarity
Binding sitei259 – 2591Substrate; via amide nitrogen By similarity
Binding sitei286 – 2861Substrate By similarity
Binding sitei445 – 4451Substrate; shared with dimeric partner By similarity
Binding sitei451 – 4511Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADP By similarity
Nucleotide bindingi33 – 353NADP By similarity
Nucleotide bindingi74 – 763NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-101-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:bbp_101
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4684686-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090030Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi224915.bbp101.

Structurei

3D structure databases

ProteinModelPortaliQ89AX5.
SMRiQ89AX5. Positions 1-468.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1303Substrate binding By similarity
Regioni185 – 1862Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89AX5-1 [UniParc]FASTAAdd to Basket

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MAKQQIGVIG MAVMGRNLAL NMERNQYTVS IFNRSLDITE KIILNNPNKN    50
LFPFFSIKDF VLSLIVPRCI VLMIKSGVAT DDTIKSLIPY LSKGDIIIDG 100
GNTFYKDTIQ RGYELLKIGV NLIGAGFSGG EKGALYGPSI MPGGRQEAYN 150
YVSPILKKIA SNSEGIPCVT YIGPDGSGHY VKMVHNGIEY GDMQLIAESY 200
FILKTLLRLD NQSISKIFDI WNQGELNSYL IDITKDILIK KDDQNNYLID 250
CILDEGSSKG TGTWTTKSAL DLNEPLTLIT ESVFFRYLSS LKSQRLLASK 300
ILCGPKDFFI VLNRDDFIEK IRQALYLGKI ISYAQGFSQL NSASQKYNWN 350
LKLGEISRIF QSGCIIRAKL LKNITQEYSS NNNFVNLLLT PYFREIANTY 400
HSSLREIVSI SVKYGIPIPA LSSAISYFDS YRSAFLPSNL IQAQRDFFGA 450
HTYKRIDKSG IFHTNWYS 468
Length:468
Mass (Da):52,646
Last modified:May 30, 2003 - v1
Checksum:iC28B8C09CCB64E11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26836.1.
RefSeqiNP_777731.1. NC_004545.1.
WP_011091237.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26836; AAO26836; bbp_101.
GeneIDi1058155.
KEGGibab:bbp101.
PATRICi21244981. VBIBucAph80364_0098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26836.1 .
RefSeqi NP_777731.1. NC_004545.1.
WP_011091237.1. NC_004545.1.

3D structure databases

ProteinModelPortali Q89AX5.
SMRi Q89AX5. Positions 1-468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO26836 ; AAO26836 ; bbp_101 .
GeneIDi 1058155.
KEGGi bab:bbp101.
PATRICi 21244981. VBIBucAph80364_0098.

Phylogenomic databases

eggNOGi COG0362.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci BAPH224915:GJ9D-101-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry namei6PGD_BUCBP
AccessioniPrimary (citable) accession number: Q89AX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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