Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Riboflavin synthase

Gene

ribE

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribE)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137Lumazine 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Ordered Locus Names:bbp_107
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681621 – 212Riboflavin synthaseAdd BLAST212

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi224915.bbp107.

Structurei

3D structure databases

ProteinModelPortaliQ89AX1.
SMRiQ89AX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 97Lumazine-binding 1Add BLAST97
Repeati98 – 195Lumazine-binding 2Add BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 6Lumazine 1 bindingBy similarity3
Regioni48 – 50Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni62 – 67Lumazine 2 binding; shared with one trimeric partnerBy similarity6
Regioni101 – 103Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni146 – 148Lumazine 1 bindingBy similarity3
Regioni160 – 165Lumazine 1 bindingBy similarity6

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108R6K. Bacteria.
COG0307. LUCA.
KOiK00793.
OMAiHILSGHV.
OrthoDBiPOG091H00EJ.

Family and domain databases

CDDicd00402. Riboflavin_synthase_like. 1 hit.
Gene3Di2.40.30.20. 2 hits.
InterProiView protein in InterPro
IPR023366. ATP_synth_asu-like_sf.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiView protein in Pfam
PF00677. Lum_binding. 2 hits.
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiView protein in PROSITE
PS51177. LUMAZINE_BIND. 2 hits.

Sequencei

Sequence statusi: Complete.

Q89AX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTGIVRGLG KVVKILKEKK ISQWEVETSN ELVKNLMLGA SISCNGCCLT
60 70 80 90 100
VRNIFRTIFC VDIVEETLRS TSLNTIIVGQ YINLERSIKF GEEVGGHLVS
110 120 130 140 150
GHIITTGVVS DKKELFSNQE LWISLSASFF IKYFFYKGFV CVDGISLTIG
160 170 180 190 200
SIKNNAFCVF LIPETILRTT IGQKIIGDVV NIEIDFYTQI TVDSVERLLK
210
VHPSKFINCI DI
Length:212
Mass (Da):23,742
Last modified:June 1, 2003 - v1
Checksum:iC0C426970FF36138
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO26841.1.

Genome annotation databases

EnsemblBacteriaiAAO26841; AAO26841; bbp_107.
KEGGibab:bbp_107.

Similar proteinsi

Entry informationi

Entry nameiRISA_BUCBP
AccessioniPrimary (citable) accession number: Q89AX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways