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Q89AW0 (AROH_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
EC=2.5.1.54
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase
Gene names
Name:aroH
Ordered Locus Names:bbp_118
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

Catalytic activity

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.

Sequence similarities

Belongs to the class-I DAHP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-deoxy-7-phosphoheptulonate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive
PRO_0000140839

Sequences

Sequence LengthMass (Da)Tools
Q89AW0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 0FAA40909DE764FD

FASTA34838,539
        10         20         30         40         50         60 
MKKTDELRTI RIDPLVTPAE LAQRHVITPS IMDTVISTRK NIANIMTGLD PRLLVIIGPC 

        70         80         90        100        110        120 
SVHDPVAAVE YAGRLQVLRK KYESRLEIVM RTYFEKPRTV IGWKGLISDP DLNGSFHVNN 

       130        140        150        160        170        180 
GLSIARKLLL DINKLGVPAA TEFLDMVIGQ FIADLISWGA IGARTTESQI HREMASALSC 

       190        200        210        220        230        240 
PVGFKNGTDG NIRIAVDAIR AASVEHLFLA PNKYGQMTIN YTSGNPFGHV IMRGGKSPNY 

       250        260        270        280        290        300 
HAKDIAIAIK YLHEFTLSEY LMIDFSHGNC LKQHRRQLDV GESIAKQIRD GSTAIFGVMI 

       310        320        330        340 
ESFLEEGSQK VIDNKSLVYG KSITDPCLGW NDSAFLLEKL ANAVDSRF

« Hide

References

[1]"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016826 Genomic DNA. Translation: AAO26852.1.
RefSeqNP_777747.1. NC_004545.1.

3D structure databases

ProteinModelPortalQ89AW0.
SMRQ89AW0. Positions 6-347.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002662; EBBUCP00000002486; EBBUCG00000002662.
GeneID1058216.
GenomeReviewsGene locus bbp_118 in contig AE016826_GR.
KEGGbab:bbp118.
PATRIC21245015. VBIBucAph80364_0114.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008184.
HOGENOMHBG670536.
OMAHRELASH.
ProtClustDBPRK09261.

Enzyme and pathway databases

BioCycBAPH224915:BBP_118-MONOMER.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01626.
PANTHERPTHR21225. AroFGH. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsTIGR00034. AroFGH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROH_BUCBP
AccessionPrimary (citable) accession number: Q89AW0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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