Reviewed, UniProtKB/Swiss-Prot Q89AV3 (APAH_BUCBP)

Names and origin

Protein names

Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene names

Name:	apaH
Ordered Locus Names:	bbp_132

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_0000197983

Sequences

	Sequence		Length	Mass (Da)
	Q89AV3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D24AF9A3B5E0EC29	FASTA	278	32,363
	10 20 30 40 50 60 MSTYFIGDIH GCFNELMHLL EKVSFDANSD VLWLTGDLIN RGPKSLEVLR FVSSLGDNVK 70 80 90 100 110 120 MVLGNHDVNL IALYASIKNS KKSSLMNNLL KSHDIDYLIY WLRKQPLFRV DHKKKIIMSH 130 140 150 160 170 180 AGMYPYWDIQ TASCYAKKIE SMLCNHNYDT FLDFLYNNSD IKSKLYECTV FKNRELECLK 190 200 210 220 230 240 LALNVFTRMR YCLPNGELDM TCKQSPSKNI SSLLPWFFIK NSCLEDYCVF FGHWASLEKN 250 260 270 ITPKNIISLD TGCCWGGILS MFRLEDKKWF VQESEIKK

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016826 Genomic DNA. Translation: AAO26866.1.
RefSeq	NP_777761.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1058166.
GenomeReviews	Gene locus bbp_132 in contig AE016826_GR.
KEGG	bab:bbp132.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89AV3.
OMA	Q89AV3. LVFGHWA.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_132-MON.
Family and domain databases
HAMAP	MF_00199. [Tree]
InterPro	IPR004617. ApaH. IPR004843. M-pesterase. IPR006186. T_phtase_apaH. [Graphical view]
PANTHER	PTHR11668. T_phtase_apaH. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_BUCBP

Accession

Primary (citable) accession number: Q89AV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)