Reviewed, UniProtKB/Swiss-Prot Q89AU6 (NUOA_BUCBP)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit A
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit A
    NDH-1 subunit A

Gene names

Name:	nuoA
Ordered Locus Names:	bbp_143

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD(+) + quinol.
Subunit structure	Composed of 13 different subunits. Subunits nuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the complex I subunit 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	NADH-quinone oxidoreductase subunit A		PRO_0000117868
Regions
	Transmembrane	14 – 34	21	Potential
	Transmembrane	66 – 86	21	Potential
	Transmembrane	96 – 116	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q89AU6-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 3A8CA3AAB13363B7	FASTA	132	15,109
	10 20 30 40 50 60 MLKSSVIAAQ YWAFFTFFFI AVSICVFMLS ISWILGGRSS SRYKNTPFES GIVPTNTTNM 70 80 90 100 110 120 YCSVKFYLVA IYFVLFDVEA LYLYAWSVSI VECGWIGFIE ALIFILFLLS GLIYLISSKL 130 LVWKSKNNIH VT

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016826 Genomic DNA. Translation: AAO26877.1.
RefSeq	NP_777772.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1058564.
GenomeReviews	Gene locus bbp_143 in contig AE016826_GR.
KEGG	bab:bbp143.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89AU6.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_143-MON.
Family and domain databases
InterPro	IPR000440. Oxidored_q4. [Graphical view]
PANTHER	PTHR11058. Oxidored_q4. 1 hit.
Pfam	PF00507. Oxidored_q4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOA_BUCBP

Accession

Primary (citable) accession number: Q89AU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2003
Last modified:	November 25, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)