Reviewed, UniProtKB/Swiss-Prot Q89AU4 (NUOCD_BUCBP)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit C/D
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit C/D
    NDH-1 subunit C/D

Gene names

Name:	nuoCD
Ordered Locus Names:	bbp_145

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	597 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD(+) + quinol.
Subunit structure	Composed of 13 different subunits. Subunits nuoCD, E, F, and G constitute the peripheral sector of the complex By similarity.
Sequence similarities	In the N-terminal section; belongs to the complex I 30 kDa subunit family. In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 597	597	NADH-quinone oxidoreductase subunit C/D		PRO_0000118683
Regions
	Region	1 – 188	188	NADH dehydrogenase I subunit C
	Region	211 – 597	387	NADH dehydrogenase I subunit D

Sequences

	Sequence		Length	Mass (Da)
	Q89AU4-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 480D38EFDEE505FA	FASTA	597	69,110
	10 20 30 40 50 60 MKKEIKRDDV NVIEKDFGNN NSIILKLFKK FGEDSFFIQT TVTDIIVLWI DGSLLLALAK 70 80 90 100 110 120 FLLTINNPYN MLFDLYGIDE RMRLYKHNLP LSHFSVVYHF ISINRNSDII LKIALLEEKL 130 140 150 160 170 180 SLPTLTKLYP NANWYEREIW DMFGISFENH PNLIRILMPK TWVGHPLRKD HPARATEFDP 190 200 210 220 230 240 YVLNKYKEDI EMEALKFKPE EWGMKKNKQS KYMFLNLGPN HPSAHGAFRI ILQLDGEEIV 250 260 270 280 290 300 DCVPDIGYHH RGAEKMGERQ TWHNYIPYTD RVEYLGGCIN EMPYVLAVER LAGIEVSQRI 310 320 330 340 350 360 EVIRIMLSEL FRINSHLLFI STFIQDVGAM TPVFLAFTDR QKIYDLIELI TGSRMHPAWF 370 380 390 400 410 420 RIGGLAHDLP KGWNALLKEF LLWMPKRLLK YINVALKNSI LISRSKGIAE YNKHDALLWG 430 440 450 460 470 480 VTGAGLRATG INFDVRKKRP YSGYQNFDFE VPIGAGISDC YSRVMLKLEE IWQSLAILKQ 490 500 510 520 530 540 CLENMPEGPF KMDHPNTTPP HKVRTLQHIE TMISHFLKVS WGPVLSSNES FKMVEATKGI 550 560 570 580 590 NSYYLISDGN TMSYRTRIRT PSFPHLQQIP SVIRGNLISD LIAYLGSIDF VMSDVDR

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016826 Genomic DNA. Translation: AAO26879.1.
RefSeq	NP_777774.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1058218.
GenomeReviews	Gene locus bbp_145 in contig AE016826_GR.
KEGG	bab:bbp145.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89AU4.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_145-MON.
Family and domain databases
InterPro	IPR014029. NADH-UbQ_OxRdtase_49kDa_CS. IPR010219. NADH_DH_1_dsu. IPR010218. NADH_DH_csu. IPR001268. NADH_DHase_Ub_30kDa_su. IPR001135. NADH_UbQ_OxRdtase_49kDa. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. PF00346. Complex1_49kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit. TIGR01962. NuoD. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. False negative. PS00535. COMPLEX1_49K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOCD_BUCBP

Accession

Primary (citable) accession number: Q89AU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2003
Last modified:	November 25, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)