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Protein

Acetate kinase

Gene

ackA

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10MagnesiumUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Active sitei150Proton donor/acceptorUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1
Sitei243Transition state stabilizerUniRule annotation1
Metal bindingi387MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 214ATPUniRule annotation5
Nucleotide bindingi285 – 287ATPUniRule annotation3
Nucleotide bindingi333 – 337ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH224915:G1G09-167-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:bbp_164
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075401 – 400Acetate kinaseAdd BLAST400

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224915.bbp164.

Structurei

3D structure databases

ProteinModelPortaliQ89AS8.
SMRiQ89AS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
KOiK00925.
OMAiWKALTGT.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89AS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNKLVLILN CGSSSLKFSV VSSDNYTTKL SGIVEFLNLS QIRFFWKIKK
60 70 80 90 100
KEYVRVINKS KSYDYALNYI LTKILKEESK IFNNIACVGH RVVHGGVNLN
110 120 130 140 150
KSVLITQEII KLITDACSFA PLHNPINLLG IKASHAVLPH LKEKNVAVFD
160 170 180 190 200
TSFHSSIPKF AYLYAIPYKF YKKFGIRKYG AHGISCQYSV CRSSELLQIE
210 220 230 240 250
LTSLNIIICH LGGGASVSVV KNGVCVDTSM GLTPLEGLIM GTRSGDIDPS
260 270 280 290 300
VIFFMNKQLN LSISTINNIL INKSGLLGLS GVSSDFRNLE SEYNSNIRIK
310 320 330 340 350
LAIDMFCYRL SKYISGYMSV VKGKLHGIVF TGGIGENSSL VRSIVISKLA
360 370 380 390 400
FLNFKLNSDI NMLMKSGKEG FINIKNTFPI LVIPANEELI IAKESFSEIN
Length:400
Mass (Da):44,388
Last modified:May 30, 2003 - v1
Checksum:iDB7644AE6A79DC1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO26897.1.
RefSeqiWP_011091298.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26897; AAO26897; bbp_164.
KEGGibab:bbp_164.

Similar proteinsi

Entry informationi

Entry nameiACKA_BUCBP
AccessioniPrimary (citable) accession number: Q89AS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome