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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Iron 1PROSITE-ProRule annotation1
Metal bindingi116Iron 1PROSITE-ProRule annotation1
Metal bindingi116Iron 2By similarity1
Metal bindingi119Iron 1PROSITE-ProRule annotation1
Active sitei123PROSITE-ProRule annotation1
Metal bindingi205Iron 2By similarity1
Metal bindingi239Iron 2By similarity1
Metal bindingi242Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciBAPH224915:G1G09-170-MONOMER
UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:bbp_167
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904721 – 376Ribonucleoside-diphosphate reductase subunit betaAdd BLAST376

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi224915.bbp167

Structurei

3D structure databases

ProteinModelPortaliQ89AS5
SMRiQ89AS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E05 Bacteria
COG0208 LUCA
KOiK00526
OMAiFYVGFVQ
OrthoDBiPOG091H04N9

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.20, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR012348 RNR-like
IPR033909 RNR_small
IPR030475 RNR_small_AS
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00368 RIBORED_SMALL, 1 hit

Sequencei

Sequence statusi: Complete.

Q89AS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYTTFSKNK NNQLYEPMFF GQSVNISRYD QQKYEIFEKL IEKQLSFFWR
60 70 80 90 100
PEEVDLSRDY IDFQNLPQHE KHIFVSNLKY QTLLDSIQGR SPNIALLPIV
110 120 130 140 150
SLPELETWIE TWSFSETIHS RSYTHIIRNI INTPSLIFDD IIDNKNIANR
160 170 180 190 200
AKDIAKYYDD LIELTSYWHL FGEGKHTING KKIKIDLHEL KKKLYLCLIS
210 220 230 240 250
VNALEAIRFY VSFACSFAFA EREKMEGNAK IIRLIARDEA LHLTSTQHIL
260 270 280 290 300
NILHNDKNNE GMSDISKECY EECYHLFIRV SDQEKIWAKY LFQNGSMLGL
310 320 330 340 350
NQEILSQYIE YITNIRMKAI GLPSPFKILS NPIPWINSWL ISDNVQVAPQ
360 370
EISVSSYLIG QINSEINDSD FEKFKL
Length:376
Mass (Da):44,123
Last modified:June 1, 2003 - v1
Checksum:i810DC5D80E6F060A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA Translation: AAO26900.1
RefSeqiWP_011091301.1, NC_004545.1

Genome annotation databases

EnsemblBacteriaiAAO26900; AAO26900; bbp_167
KEGGibab:bbp_167

Similar proteinsi

Entry informationi

Entry nameiRIR2_BUCBP
AccessioniPrimary (citable) accession number: Q89AS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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