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Q89AS5

- RIR2_BUCBP

UniProt

Q89AS5 - RIR2_BUCBP

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Iron 1PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron 1PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron 2By similarity
    Metal bindingi119 – 1191Iron 1PROSITE-ProRule annotation
    Active sitei123 – 1231PROSITE-ProRule annotation
    Metal bindingi205 – 2051Iron 2By similarity
    Metal bindingi239 – 2391Iron 2By similarity
    Metal bindingi242 – 2421Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-167-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdB
    Ordered Locus Names:bbp_167
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Ribonucleoside-diphosphate reductase subunit betaPRO_0000190472Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi224915.bbp167.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89AS5.
    SMRiQ89AS5. Positions 3-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    KOiK00526.
    OMAiWIETWAF.
    OrthoDBiEOG6J48J7.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 2 hits.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89AS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYTTFSKNK NNQLYEPMFF GQSVNISRYD QQKYEIFEKL IEKQLSFFWR    50
    PEEVDLSRDY IDFQNLPQHE KHIFVSNLKY QTLLDSIQGR SPNIALLPIV 100
    SLPELETWIE TWSFSETIHS RSYTHIIRNI INTPSLIFDD IIDNKNIANR 150
    AKDIAKYYDD LIELTSYWHL FGEGKHTING KKIKIDLHEL KKKLYLCLIS 200
    VNALEAIRFY VSFACSFAFA EREKMEGNAK IIRLIARDEA LHLTSTQHIL 250
    NILHNDKNNE GMSDISKECY EECYHLFIRV SDQEKIWAKY LFQNGSMLGL 300
    NQEILSQYIE YITNIRMKAI GLPSPFKILS NPIPWINSWL ISDNVQVAPQ 350
    EISVSSYLIG QINSEINDSD FEKFKL 376
    Length:376
    Mass (Da):44,123
    Last modified:June 1, 2003 - v1
    Checksum:i810DC5D80E6F060A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO26900.1.
    RefSeqiNP_777795.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO26900; AAO26900; bbp_167.
    GeneIDi1058229.
    KEGGibab:bbp167.
    PATRICi21245111. VBIBucAph80364_0162.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO26900.1 .
    RefSeqi NP_777795.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali Q89AS5.
    SMRi Q89AS5. Positions 3-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO26900 ; AAO26900 ; bbp_167 .
    GeneIDi 1058229.
    KEGGi bab:bbp167.
    PATRICi 21245111. VBIBucAph80364_0162.

    Phylogenomic databases

    eggNOGi COG0208.
    KOi K00526.
    OMAi WIETWAF.
    OrthoDBi EOG6J48J7.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci BAPH224915:GJ9D-167-MONOMER.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiRIR2_BUCBP
    AccessioniPrimary (citable) accession number: Q89AS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3