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Q89AS5

- RIR2_BUCBP

UniProt

Q89AS5 - RIR2_BUCBP

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Protein
Ribonucleoside-diphosphate reductase subunit beta
Gene
nrdB, bbp_167
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Iron 1 By similarity
Metal bindingi116 – 1161Iron 1 By similarity
Metal bindingi116 – 1161Iron 2 By similarity
Metal bindingi119 – 1191Iron 1 By similarity
Active sitei123 – 1231 By similarity
Metal bindingi205 – 2051Iron 2 By similarity
Metal bindingi239 – 2391Iron 2 By similarity
Metal bindingi242 – 2421Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-167-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:bbp_167
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190472Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi224915.bbp167.

Structurei

3D structure databases

ProteinModelPortaliQ89AS5.
SMRiQ89AS5. Positions 3-342.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiWIETWAF.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89AS5-1 [UniParc]FASTAAdd to Basket

« Hide

MTYTTFSKNK NNQLYEPMFF GQSVNISRYD QQKYEIFEKL IEKQLSFFWR    50
PEEVDLSRDY IDFQNLPQHE KHIFVSNLKY QTLLDSIQGR SPNIALLPIV 100
SLPELETWIE TWSFSETIHS RSYTHIIRNI INTPSLIFDD IIDNKNIANR 150
AKDIAKYYDD LIELTSYWHL FGEGKHTING KKIKIDLHEL KKKLYLCLIS 200
VNALEAIRFY VSFACSFAFA EREKMEGNAK IIRLIARDEA LHLTSTQHIL 250
NILHNDKNNE GMSDISKECY EECYHLFIRV SDQEKIWAKY LFQNGSMLGL 300
NQEILSQYIE YITNIRMKAI GLPSPFKILS NPIPWINSWL ISDNVQVAPQ 350
EISVSSYLIG QINSEINDSD FEKFKL 376
Length:376
Mass (Da):44,123
Last modified:June 1, 2003 - v1
Checksum:i810DC5D80E6F060A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26900.1.
RefSeqiNP_777795.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26900; AAO26900; bbp_167.
GeneIDi1058229.
KEGGibab:bbp167.
PATRICi21245111. VBIBucAph80364_0162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26900.1 .
RefSeqi NP_777795.1. NC_004545.1.

3D structure databases

ProteinModelPortali Q89AS5.
SMRi Q89AS5. Positions 3-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO26900 ; AAO26900 ; bbp_167 .
GeneIDi 1058229.
KEGGi bab:bbp167.
PATRICi 21245111. VBIBucAph80364_0162.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi WIETWAF.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci BAPH224915:GJ9D-167-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 2 hits.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiRIR2_BUCBP
AccessioniPrimary (citable) accession number: Q89AS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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