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Q89AS5 (RIR2_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdB
Ordered Locus Names:bbp_167
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190472

Sites

Active site1231 By similarity
Metal binding851Iron 1 By similarity
Metal binding1161Iron 1 By similarity
Metal binding1161Iron 2 By similarity
Metal binding1191Iron 1 By similarity
Metal binding2051Iron 2 By similarity
Metal binding2391Iron 2 By similarity
Metal binding2421Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q89AS5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 810DC5D80E6F060A

FASTA37644,123
        10         20         30         40         50         60 
MTYTTFSKNK NNQLYEPMFF GQSVNISRYD QQKYEIFEKL IEKQLSFFWR PEEVDLSRDY 

        70         80         90        100        110        120 
IDFQNLPQHE KHIFVSNLKY QTLLDSIQGR SPNIALLPIV SLPELETWIE TWSFSETIHS 

       130        140        150        160        170        180 
RSYTHIIRNI INTPSLIFDD IIDNKNIANR AKDIAKYYDD LIELTSYWHL FGEGKHTING 

       190        200        210        220        230        240 
KKIKIDLHEL KKKLYLCLIS VNALEAIRFY VSFACSFAFA EREKMEGNAK IIRLIARDEA 

       250        260        270        280        290        300 
LHLTSTQHIL NILHNDKNNE GMSDISKECY EECYHLFIRV SDQEKIWAKY LFQNGSMLGL 

       310        320        330        340        350        360 
NQEILSQYIE YITNIRMKAI GLPSPFKILS NPIPWINSWL ISDNVQVAPQ EISVSSYLIG 

       370 
QINSEINDSD FEKFKL 

« Hide

References

[1]"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016826 Genomic DNA. Translation: AAO26900.1.
RefSeqNP_777795.1. NC_004545.1.

3D structure databases

ProteinModelPortalQ89AS5.
SMRQ89AS5. Positions 3-342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224915.bbp167.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO26900; AAO26900; bbp_167.
GeneID1058229.
KEGGbab:bbp167.
PATRIC21245111. VBIBucAph80364_0162.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0208.
KOK00526.
OMAWIETWAF.
OrthoDBEOG6J48J7.
ProtClustDBPRK09101.

Enzyme and pathway databases

BioCycBAPH224915:GJ9D-167-MONOMER.
UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_BUCBP
AccessionPrimary (citable) accession number: Q89AS5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: December 11, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways