Reviewed, UniProtKB/Swiss-Prot Q89AR5 (THRC_BUCBP)

Names and origin

Protein names

Recommended name:
    Threonine synthase
    EC=4.2.3.1

Gene names

Name:	thrC
Ordered Locus Names:	bbp_181

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 430	430	Threonine synthase		PRO_0000185629
Amino acid modifications
	Modified residue	108	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q89AR5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 27FEEAFCFC7FB260	FASTA	430	48,632
	10 20 30 40 50 60 MKLYNLKKKQ DQVNFSKAVK LGLGKNQGLF FPKELPILTK EQLYKLLKMD FLTRSSKILS 70 80 90 100 110 120 MFIGDEIHYS ELTKRIKNAF SFTTPKIVSI SKNIACFELF HGPTLAFKDF GARFMAQILS 130 140 150 160 170 180 FLNHDKNDTI TILTATSGDT GAAVAHAFFK MKNVRVIILY PKGKISELQE KLFCTLGENI 190 200 210 220 230 240 ITIAVNGSFD ECQKLVKQAF NDDQLRIETG LNSANSINIS RLLAQICYYF EAFALLTKKQ 250 260 270 280 290 300 QKNLVISVPC GNFGNLTAGL LAKALGLPIK SFIASTNSND TVPRFLKTGF WKPNNTVSTI 310 320 330 340 350 360 SNAMDISQPN NWPRVEELFK RKFWSLKTLK YGSVSDILTK KSLKKLAFLG YVSEPHAAVA 370 380 390 400 410 420 YYTLKNKLKQ NEFGLFLGTA HPAKFKKTIE KILQITLFLP SKLRNQIKLP LLSHNIRPDF 430 SKLKKFLLEK

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016826 Genomic DNA. Translation: AAO26913.1.
RefSeq	NP_777808.1.
3D structure databases
HSSP	HSSP built from PDB template 1KL7 based on UniProtKB P16120.
ModBase	Search...
Genome annotation databases
GeneID	1058160.
GenomeReviews	Gene locus bbp_181 in contig AE016826_GR.
KEGG	bab:bbp181.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89AR5.
OMA	MAVMECD.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_181-MON.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_BUCBP

Accession

Primary (citable) accession number: Q89AR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)