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Q89AR5

- THRC_BUCBP

UniProt

Q89AR5 - THRC_BUCBP

Protein

Threonine synthase

Gene

thrC

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-181-MONOMER.
    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrC
    Ordered Locus Names:bbp_181
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Threonine synthasePRO_0000185629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei108 – 1081N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi224915.bbp181.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89AR5.
    SMRiQ89AR5. Positions 1-428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0498.
    KOiK01733.
    OMAiSDTANFA.
    OrthoDBiEOG65BDJX.

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89AR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLYNLKKKQ DQVNFSKAVK LGLGKNQGLF FPKELPILTK EQLYKLLKMD    50
    FLTRSSKILS MFIGDEIHYS ELTKRIKNAF SFTTPKIVSI SKNIACFELF 100
    HGPTLAFKDF GARFMAQILS FLNHDKNDTI TILTATSGDT GAAVAHAFFK 150
    MKNVRVIILY PKGKISELQE KLFCTLGENI ITIAVNGSFD ECQKLVKQAF 200
    NDDQLRIETG LNSANSINIS RLLAQICYYF EAFALLTKKQ QKNLVISVPC 250
    GNFGNLTAGL LAKALGLPIK SFIASTNSND TVPRFLKTGF WKPNNTVSTI 300
    SNAMDISQPN NWPRVEELFK RKFWSLKTLK YGSVSDILTK KSLKKLAFLG 350
    YVSEPHAAVA YYTLKNKLKQ NEFGLFLGTA HPAKFKKTIE KILQITLFLP 400
    SKLRNQIKLP LLSHNIRPDF SKLKKFLLEK 430
    Length:430
    Mass (Da):48,632
    Last modified:June 1, 2003 - v1
    Checksum:i27FEEAFCFC7FB260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO26913.1.
    RefSeqiNP_777808.1. NC_004545.1.
    WP_011091314.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO26913; AAO26913; bbp_181.
    GeneIDi1058160.
    KEGGibab:bbp181.
    PATRICi21245137. VBIBucAph80364_0175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO26913.1 .
    RefSeqi NP_777808.1. NC_004545.1.
    WP_011091314.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali Q89AR5.
    SMRi Q89AR5. Positions 1-428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO26913 ; AAO26913 ; bbp_181 .
    GeneIDi 1058160.
    KEGGi bab:bbp181.
    PATRICi 21245137. VBIBucAph80364_0175.

    Phylogenomic databases

    eggNOGi COG0498.
    KOi K01733.
    OMAi SDTANFA.
    OrthoDBi EOG65BDJX.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .
    BioCyci BAPH224915:GJ9D-181-MONOMER.

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiTHRC_BUCBP
    AccessioniPrimary (citable) accession number: Q89AR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3