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Protein

Threonine synthase

Gene

thrC

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi: L-threonine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBAPH224915:G1G09-184-MONOMER
UniPathwayiUPA00050; UER00065

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:bbp_181
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856291 – 430Threonine synthaseAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ89AR5

Interactioni

Protein-protein interaction databases

STRINGi224915.bbp181

Structurei

3D structure databases

ProteinModelPortaliQ89AR5
SMRiQ89AR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105D98 Bacteria
COG0498 LUCA
KOiK01733
OMAiYNIKHPE
OrthoDBiPOG091H02AJ

Family and domain databases

Gene3Di3.90.1380.10, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PF14821 Thr_synth_N, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit

Sequencei

Sequence statusi: Complete.

Q89AR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYNLKKKQ DQVNFSKAVK LGLGKNQGLF FPKELPILTK EQLYKLLKMD
60 70 80 90 100
FLTRSSKILS MFIGDEIHYS ELTKRIKNAF SFTTPKIVSI SKNIACFELF
110 120 130 140 150
HGPTLAFKDF GARFMAQILS FLNHDKNDTI TILTATSGDT GAAVAHAFFK
160 170 180 190 200
MKNVRVIILY PKGKISELQE KLFCTLGENI ITIAVNGSFD ECQKLVKQAF
210 220 230 240 250
NDDQLRIETG LNSANSINIS RLLAQICYYF EAFALLTKKQ QKNLVISVPC
260 270 280 290 300
GNFGNLTAGL LAKALGLPIK SFIASTNSND TVPRFLKTGF WKPNNTVSTI
310 320 330 340 350
SNAMDISQPN NWPRVEELFK RKFWSLKTLK YGSVSDILTK KSLKKLAFLG
360 370 380 390 400
YVSEPHAAVA YYTLKNKLKQ NEFGLFLGTA HPAKFKKTIE KILQITLFLP
410 420 430
SKLRNQIKLP LLSHNIRPDF SKLKKFLLEK
Length:430
Mass (Da):48,632
Last modified:June 1, 2003 - v1
Checksum:i27FEEAFCFC7FB260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA Translation: AAO26913.1
RefSeqiWP_011091314.1, NC_004545.1

Genome annotation databases

EnsemblBacteriaiAAO26913; AAO26913; bbp_181
KEGGibab:bbp_181

Similar proteinsi

Entry informationi

Entry nameiTHRC_BUCBP
AccessioniPrimary (citable) accession number: Q89AR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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