Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:bbp_189
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622421 – 887Pyruvate dehydrogenase E1 componentAdd BLAST887

Proteomic databases

PRIDEiQ89AR0.

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi224915.bbp189.

Structurei

3D structure databases

ProteinModelPortaliQ89AR0.
SMRiQ89AR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105DAQ. Bacteria.
COG2609. LUCA.
KOiK00163.
OMAiREPWFPG.
OrthoDBiPOG091H046S.

Family and domain databases

CDDicd02017. TPP_E1_EcPDC_like. 1 hit.
Gene3Di3.40.50.920. 1 hit.
InterProiView protein in InterPro
IPR004660. 2-oxoA_DH_E1.
IPR035807. PDC_E1_N.
IPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005474. Transketolase_N.
PANTHERiPTHR43825:SF3. PTHR43825:SF3. 1 hit.
PfamiView protein in Pfam
PF00456. Transketolase_N. 1 hit.
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89AR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFSSNDID PIETEDWIQA IKSVIREDGL ERANFIINTV KKYVPYKNKV
60 70 80 90 100
VFKKCAISNY VNTIPVEEEP NYPGDLFIEQ KIRSVIRWNA IMMVLRASKK
110 120 130 140 150
NLDLGGHLSS FQSAATIYEV CFNHFFHATN ENNGGDLVYF QGHISPGIYS
160 170 180 190 200
RAFIEDRLTQ KQLDNFRQEI DGIGLSSYPH PKLMPNFWQF PTVSMGLGPI
210 220 230 240 250
CAIYQAKFLK YLEHRNLKCT NNQKVYAFLG DGEMDEPESK GAISIAAREK
260 270 280 290 300
LDNLIFIVNC NLQRLDGPVI GNGKVIDELE SVFKGCGWKV IKVIWGSKWD
310 320 330 340 350
SLLKKDVSGK LIKLMNETLD GDYQTFKSKN GAYIRKYFFG KYLETQELVK
360 370 380 390 400
DMSDDQIWNL DRGGHDPKKI YAALSKANSI VGKPVIILMH TVKGYGMGDI
410 420 430 440 450
AEGKNIAHQI KKIDIKGITY IKNRFKVPVE ENELKYLPYV SFDANSIEYK
460 470 480 490 500
YLHARRKKLG GYLPIRLSNF TNFFTLPKLD EFSTLLTEQK KEISTTIVFI
510 520 530 540 550
RILNILLRNS FIKDRIVPII ADEARTFGME GLFRKIGIYN FIGQKYTPQD
560 570 580 590 600
KELLAYYKED KKGQILQEGI NELGAAASWL AAATSYSTNN FPMIPFYIFY
610 620 630 640 650
SMFGFQRIGD LFWAAGDQQA RGFLIGGTSG KTTLNGEGLQ HGDGHSHIQA
660 670 680 690 700
LTIPNCISYN PAYAYELAVI VHDGLQRMYG PSQENIYYYI TTMNENYVMP
710 720 730 740 750
GISKNMYEGI CKGIYKLKHV GKKNVKVQIM GSGSILQCVC RAAEILLEEY
760 770 780 790 800
DIGSDVYSVT SFTELARNGQ DCDRWNLLHP TQEKKVPFVT KIMNKLPAIA
810 820 830 840 850
VTDYMKLFSE QVRAYIPAVT YRVLGTDGFG RSDSRKNLRR YFEIDEYHIV
860 870 880
IAVLGELEKI GDVDKNTIVN AISKFKIDIN KVNPRLA
Length:887
Mass (Da):100,906
Last modified:June 16, 2003 - v1
Checksum:i89A9A18649A6A78A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO26921.1.
RefSeqiWP_011091322.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26921; AAO26921; bbp_189.
KEGGibab:bbp_189.

Similar proteinsi

Entry informationi

Entry nameiODP1_BUCBP
AccessioniPrimary (citable) accession number: Q89AR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: November 22, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome