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Q89AR0

- ODP1_BUCBP

UniProt

Q89AR0 - ODP1_BUCBP

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Protein
Pyruvate dehydrogenase E1 component
Gene
aceE, bbp_189
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-189-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:bbp_189
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Pyruvate dehydrogenase E1 component
PRO_0000162242Add
BLAST

Proteomic databases

PRIDEiQ89AR0.

Interactioni

Subunit structurei

Homodimer By similarity. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Protein-protein interaction databases

STRINGi224915.bbp189.

Structurei

3D structure databases

ProteinModelPortaliQ89AR0.
SMRiQ89AR0. Positions 57-887.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
KOiK00163.
OMAiKGIYKLD.
OrthoDBiEOG6BW4TW.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89AR0-1 [UniParc]FASTAAdd to Basket

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MAEFSSNDID PIETEDWIQA IKSVIREDGL ERANFIINTV KKYVPYKNKV    50
VFKKCAISNY VNTIPVEEEP NYPGDLFIEQ KIRSVIRWNA IMMVLRASKK 100
NLDLGGHLSS FQSAATIYEV CFNHFFHATN ENNGGDLVYF QGHISPGIYS 150
RAFIEDRLTQ KQLDNFRQEI DGIGLSSYPH PKLMPNFWQF PTVSMGLGPI 200
CAIYQAKFLK YLEHRNLKCT NNQKVYAFLG DGEMDEPESK GAISIAAREK 250
LDNLIFIVNC NLQRLDGPVI GNGKVIDELE SVFKGCGWKV IKVIWGSKWD 300
SLLKKDVSGK LIKLMNETLD GDYQTFKSKN GAYIRKYFFG KYLETQELVK 350
DMSDDQIWNL DRGGHDPKKI YAALSKANSI VGKPVIILMH TVKGYGMGDI 400
AEGKNIAHQI KKIDIKGITY IKNRFKVPVE ENELKYLPYV SFDANSIEYK 450
YLHARRKKLG GYLPIRLSNF TNFFTLPKLD EFSTLLTEQK KEISTTIVFI 500
RILNILLRNS FIKDRIVPII ADEARTFGME GLFRKIGIYN FIGQKYTPQD 550
KELLAYYKED KKGQILQEGI NELGAAASWL AAATSYSTNN FPMIPFYIFY 600
SMFGFQRIGD LFWAAGDQQA RGFLIGGTSG KTTLNGEGLQ HGDGHSHIQA 650
LTIPNCISYN PAYAYELAVI VHDGLQRMYG PSQENIYYYI TTMNENYVMP 700
GISKNMYEGI CKGIYKLKHV GKKNVKVQIM GSGSILQCVC RAAEILLEEY 750
DIGSDVYSVT SFTELARNGQ DCDRWNLLHP TQEKKVPFVT KIMNKLPAIA 800
VTDYMKLFSE QVRAYIPAVT YRVLGTDGFG RSDSRKNLRR YFEIDEYHIV 850
IAVLGELEKI GDVDKNTIVN AISKFKIDIN KVNPRLA 887
Length:887
Mass (Da):100,906
Last modified:June 16, 2003 - v1
Checksum:i89A9A18649A6A78A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26921.1.
RefSeqiNP_777816.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26921; AAO26921; bbp_189.
GeneIDi1058233.
KEGGibab:bbp189.
PATRICi21245153. VBIBucAph80364_0183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO26921.1 .
RefSeqi NP_777816.1. NC_004545.1.

3D structure databases

ProteinModelPortali Q89AR0.
SMRi Q89AR0. Positions 57-887.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp189.

Proteomic databases

PRIDEi Q89AR0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO26921 ; AAO26921 ; bbp_189 .
GeneIDi 1058233.
KEGGi bab:bbp189.
PATRICi 21245153. VBIBucAph80364_0183.

Phylogenomic databases

eggNOGi COG2609.
KOi K00163.
OMAi KGIYKLD.
OrthoDBi EOG6BW4TW.

Enzyme and pathway databases

BioCyci BAPH224915:GJ9D-189-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF00456. Transketolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00759. aceE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiODP1_BUCBP
AccessioniPrimary (citable) accession number: Q89AR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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