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Q89AQ2 (MURD_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
EC=6.3.2.9
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene names
Name:murD
Ordered Locus Names:bbp_200
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639

Subcellular location

Cytoplasm By similarity HAMAP MF_00639.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639
PRO_0000108985

Sequences

Sequence LengthMass (Da)Tools
Q89AQ2 [UniParc].

Last modified May 23, 2003. Version 1.
Checksum: C4876568C23CE357

FASTA44250,066
        10         20         30         40         50         60 
MTRNYLHKKI LIFGMGLTGI SCLNFFLSKG IYPKIMDTDK RPKHIEKIIK FKNICYHTGS 

        70         80         90        100        110        120 
VNYSWILQSN LIIVSPGITP SHPALKFATK KNIEIIGDIE LFVQETKVPI IAITGSNGKS 

       130        140        150        160        170        180 
SVTKIVKEII QKAGFTTYIG GNIGIPALNI VNKFAHFFIL ELSSFQLERT FSLKAYIATI 

       190        200        210        220        230        240 
LNITPDHLNR YSSDIKEYEK AKQKIYKNSK ICIINVDNPV TINRQAQLTK CISFGVHSGD 

       250        260        270        280        290        300 
YHLSHTYTNT WLCYKSLKLI NTKKLKLSGR HNYINMLSAL AIVHELKISF KISVRILKNF 

       310        320        330        340        350        360 
LGLPHRCQKV YKNNNITWIN DSKSTNIAST KSAIQSINTK GKIRLILGGD KKSSNLNLLK 

       370        380        390        400        410        420 
PILKNNAIVI YCYGKDKKEL FNLYPHKSKI FETLQEVMQH ISVQVQPGDV VLLSPACSSL 

       430        440 
DQFSGFEERG NTFVKLIQEL IH

« Hide

References

[1]"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016826 Genomic DNA. Translation: AAO26932.1.
RefSeqNP_777827.1. NC_004545.1.

3D structure databases

ProteinModelPortalQ89AQ2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002628; EBBUCP00000002452; EBBUCG00000002628.
GeneID1058151.
GenomeReviewsGene locus bbp_200 in contig AE016826_GR.
KEGGbab:bbp200.
PATRIC21245175. VBIBucAph80364_0194.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007738.
HOGENOMHBG750024.
OMALERHKTL.
PhylomeDBQ89AQ2.

Enzyme and pathway databases

BioCycBAPH224915:BBP_200-MONOMER.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURD_BUCBP
AccessionPrimary (citable) accession number: Q89AQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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