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Q89AP3 (AMPM_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methionine aminopeptidase

Short name=MAP
EC=3.4.11.18
Alternative name(s):
Peptidase M
Gene names
Name:map
Ordered Locus Names:bbp_212
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the amino-terminal methionine from nascent proteins By similarity.

Catalytic activity

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Cofactor

Binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. The enzyme is also active with zinc, manganese or divalent iron ions By similarity.

Binds 1 sodium ion per subunit. The sodium ion has a structural role By similarity.

Sequence similarities

Belongs to the peptidase M24A family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Methionine aminopeptidase
PRO_0000148931

Sites

Metal binding981Cobalt 1 By similarity
Metal binding1091Cobalt 1 By similarity
Metal binding1091Cobalt 2 By similarity
Metal binding1721Cobalt 2 By similarity
Metal binding2061Cobalt 2 By similarity
Metal binding2371Cobalt 1 By similarity
Metal binding2371Cobalt 2 By similarity
Binding site801Substrate By similarity
Binding site1791Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q89AP3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 564C2FC926EEBCA6

FASTA26630,049
        10         20         30         40         50         60 
MTCIFIKNIN EINKMRLVGK LVADVLDMIK EYIVPGITTE ELNNICHNYI TYKQHAKPAC 

        70         80         90        100        110        120 
LGYQGFPKSI CTSINDIVCH GIPNKNSILK NGDIINIDVA ILKDKYYSDA SKMFFVGKPT 

       130        140        150        160        170        180 
ELGKKLCYVA KKSLYLALYT IRPGINLQKL GKVIQNYVKK QNFSIVKEYC GHGIGRSFHE 

       190        200        210        220        230        240 
PPQILHHNYY KSNTTILQSG MTFTVEPMIN SGSCEVQCTN DGWTVKTKDK SLSAQYEHTI 

       250        260 
LVNEEGCEIL TLQKGEQISR ILKNLT 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016826 Genomic DNA. Translation: AAO26944.1.
RefSeqNP_777839.1. NC_004545.1.

3D structure databases

ProteinModelPortalQ89AP3.
ModBaseSearch...

Protein family/group databases

MEROPSM24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002208; EBBUCP00000002032; EBBUCG00000002208.
GeneID1058483.
GenomeReviewsGene locus bbp_212 in contig AE016826_GR.
KEGGbab:bbp212.
PATRIC21245199. VBIBucAph80364_0206.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008074.
HOGENOMHBG299384.
OMAHYGTRGK.

Enzyme and pathway databases

BioCycBAPH224915:BBP_212-MONOMER.

Family and domain databases

InterProIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
Gene3DG3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
KOK01265.
PfamPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSPR00599. MAPEPTIDASE.
SUPFAMSSF55920. Peptidase_M24_cat_core. 1 hit.
TIGRFAMsTIGR00500. Met_pdase_I. 1 hit.
PROSITEPS00680. MAP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPM_BUCBP
AccessionPrimary (citable) accession number: Q89AP3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families